Mariappan, Malaiyalam - Yale University - Biological & Biomedical Sciences

个人简介

M.Sc., University of Madras, India, 2001 Ph.D., University of Goettingen, Germany, 2005 PhD University of Goettingen, Germany (2005) MSc University of Madras, India (2001) Post-doctoral Fellow University of Goettingen Post-doctoral Fellow National Institutes of Health, USA

研究领域

Cell Biology; Endoplasmic Reticulum; Quality Control; Unfolded Protein Response; Protein Aggregates

近期论文

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A functional link between the co-translational protein translocation pathway and the UPR Plumb, P., Zhang, Z. R., Appathurai, S., and Mariappan. M#. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLIFE # Corresponding author The mechanisms of membrane associated steps in tail-anchored protein insertion. Mariappan, M., *Mateja, A., Dobosz, M., Bove, E., Hegde, R. S., and Keenan, R. J. (2011) The mechanisms of membrane associated steps in tail-anchored protein insertion. Nature 477, 61-66. Protein targeting and degradation pathways are coupled for elimination of mislocalized proteins. Hessa, T., Sharma, A., Mariappan, M., Eshleman, H. D., Gutierrez, E., and Hegde, R. S. (2011) Protein targeting and degradation pathways are coupled for elimination of mislocalized proteins. Nature 475, 393-397. A ribosome-associating factor chaperones tail-anchored membrane proteins. Mariappan, M., Li, X., Stefanovic, S., Sharma, A., Mateja, A., Keenan, R. J., and Hegde, R. S. (2010) A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature 466, 1120-1124. The structural basis of tail-anchored membrane protein recognition by Get3. Mateja, A., Szlachcic, A., Downing, M. E., Dobosz, M., Mariappan, M., Hegde, R. S., and Keenan, R. J. (2009) The structural basis of tail-anchored membrane protein recognition by Get3. Nature 461, 361-366. Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. Dierks, T., Dickmanns, A., Preusser-Kunze, A., Schmidt, B., Mariappan, M., von Figura, K., Ficner, R., and Rudolph, M. G. (2005) Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. Cell 121, 541-552. 541-52 Sundaram A, Plumb R, Appathurai S, Mariappan M: The Sec61 translocon limits IRE1α signaling during the unfolded protein response. Elife. 2017 May 15; 2017 May 15. PMID: 28504640 Plumb R, Zhang ZR, Appathurai S, Mariappan M: A functional link between the co-translational protein translocation pathway and the UPR. Elife. 2015 May 20; 2015 May 20. PMID: 25993558