MacMicking, John D - Yale University - Biological & Biomedical Sciences

个人简介

Dr. MacMicking began research as an undergraduate B.Sc Honours Fellow (1st Class) within the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the the John Curtin School of Medical Research, Australian National University in Canberra. He then pursued Ph. D studies with Carl Nathan in the combined Immunology program at Sloan-Kettering Institute-Cornell University Medical College in New York City before post-doctoral work as an HHMI Life Science Research Foundation Fellow and Adjunct Assistant Professor at the Rockefeller University with John McKinney. Here he identified and began characterizing members of an IFN-inducible GTPase superfamily important for cell-autonomous immunity to infection. Since joining Yale in 2004 his work in this area has been recognized through several awards, being named a 2004 Edward Mallinckrodt Jr Foundation Fellow, 2005 Searle Scholar, 2006 Cancer Research Institute Investigator, 2008 Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Disease, 2010 CCFA Senior Research Awardee, 2014 AAF Scholar and 2014 Kenneth Rainin Foundation Innovator. Dr. MacMicking was promoted to Associate Professor in 2010 and received Tenure in 2014. He was selected as a Howard Hughes Medical Institute (HHMI) Investigator in 2015 and became a member of the Yale Systems Biology Institute in 2016. PhD Cornell University (1997) BS Australian National Univ (1990) Assistant Professor (Adjunct) The Rockefeller University Research Associate The Rockefeller University HHMI LSRF Fellow The Rockefeller University Revson Biomedical Fellow The Rockefeller University

研究领域

Cell Biology; Immunity, Innate; Interferons; Microbiology; Inflammasomes; Disease Resistance

近期论文

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Interferon-induced guanylate-binding proteins in inflammasome activation and host defense. Kim, B.H., Chee, J.D., Bradfield, C.J., Park, E.S., Kumar, P., and MacMicking JD. Interferon-induced guanylate-binding proteins in inflammasome activation and host defense. Nature Immunology 17: 481-489 (2016). Cell-autonomous effector mechanisms against Mycobacterium tuberculosis. MacMicking, J.D. Cell-autonomous effector mechanisms against Mycobacterium tuberculosis. Cold Spring Harbor Perspectives in Medicine. 4: a018507 (2014). Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Das, R., Koo, M.S., Kim, B.H., Jacob, S.T., Subbian, S., Yao, J., Leng, L., Levy, R., Murchison, C., Burman, W.J., Moore, C.C., Scheld, W.M., David, J.R., Kaplan, G., MacMicking, J.D., and Bucala, R. Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proceedings of the National Academy of Science USA. 110: E2997-3006 (2013). Cellular self-defense: How cell-autonomous immunity protects against pathogens. Randow F., MacMicking, J.D., and James, L.C. Cellular self-defense: How cell-autonomous immunity protects against pathogens. Science. 340,701-706 (2013). GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Shenoy, A.R., Wellington, D.A., Kumar, P., Kassa, H., Booth, C.J., Cresswell, P., and MacMicking, J.D. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 336, 481-485 (2012). IFN-induced effector mechanisms in cell-autonomous immunity. MacMicking, J.D. IFN-induced effector mechanisms in cell-autonomous immunity. Nature Reviews of Immunology. 12, 367-382. (2012). IFN-inducible GTPases in host cell defense. Kim, B.H., Shenoy, A.R., Kumar, P., Bradfield, C.J., and MacMicking, J.D. IFN-inducible GTPases in host cell defense. Cell Host & Microbe. 12, 434-444 (2012). A family of IFN-gamma-inducible 65kD GTPases protect against bacterial infection. Kim, B.H., Shenoy, A.R., Kumar, P., Das, R., Tiwari, S., and MacMicking, J.D. A family of IFN-gamma-inducible 65kD GTPases protect against bacterial infection. Science. 332, 717-721 (2011). Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Tiwari, S., Choi, H.P., Matsuzawa, T., Pypaert, M, and MacMicking, J.D. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nature Immunology. 10: 907-917 (2009). Macrophage activation and host defense. MacMicking, J.D. Macrophage activation and host defense. Cell Host & Microbe. 5, 405-407 (2009). A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Bougneres, L., Helft, J., Tiwari, S., Vargas, P., Chang, B.H.J., Chan, L., Campisi, L., Lauvau, G., Hugues, S., Kumar, P., Kamphorst, A.O., Lennonn Dumenil, A.M., Nussenzweig, M., MacMicking, J.D., Amigorina, S., and Guemonprez, P. A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity. 31:232-244 (2009). IFN-inducible GTPases and immunity to intracellular pathogens. MacMicking, J.D. IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunology. 25, 601-609 (2004). Immune control of tuberculosis by IFN-gamma-inducible LRG-47.