Lusk, C. Patrick - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Lusk has a long standing interest in fundamental cellular mechanisms of compartmentalization with an emphasis on those that govern the biogenesis of the nuclear envelope and nuclear pore complexes (NPCs). He has been studying the nuclear envelope and nuclear transport since his graduate work at the University of Alberta in Canada and has been trained during his postdoctoral fellowship by Günter Blobel at The Rockefeller University. During this time, he (with collaborators/colleagues) has provided substantial insight into how nuclear transport is regulated and how the NPC is assembled. Moreover, he has helped to develop yeast as a model to study integral membrane proteins that reside at the inner nuclear membrane. While it is generally understood that these proteins are essential factors in gene regulation and genome organization, which is reflected by the discovery of the “nuclear envelopathies”, they remain challenging to study. Dr. Lusk is leveraging his expertise in yeast cell biology and genetics with super-resolution and proteomic approaches to illuminate function at the nuclear periphery. PhD University of Alberta (2005) BS University of Alberta (1998) Postdoctoral Fellow The Rockefeller University

研究领域

Chromatin; Chromosomes; Nuclear Envelope; Nuclear Pore; Nuclear Pore Complex Proteins

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Webster, BM, Colombi, P, Jager, J, Lusk, CP. Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Cell. 2014. 159(2): 388-401 The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. Colombi, P, Webster, BM, Frohlich, F, Lusk, C.P. The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. Journal of Cell Biology. 2013. 203(2) Lumenal interactions in nuclear pore complex assembly and stability. Yewdell, W.T., Colombi, P, Makhnevych, T., Lusk C.P. Lumenal interactions in nuclear pore complex assembly and stability. Molecular Biology of the Cell. 2011. 22(8):1375-88 Highway to the inner nuclear membrane: rules for the road. Lusk, C.P., Blobel, G., King M.C. Highway to the inner nuclear membrane: rules for the road. Nature Reviews Molecular and Cellular Biology. 2007, 8: 414-420. Karyopherin-mediated import of integral inner nuclear membrane proteins. King, M.C.*, Lusk C.P.*, G. Blobel. Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature. 2006, 442: 1003-7 * equal contributions Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes. Lusk, C.P., T. Makhnevych, M. Marelli, J.D. Aitchison, R.W. Wozniak. Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes. Journal of Cell Biology. 2002, 159: 267-278. Lusk CP, King MC: The nucleus: keeping it together by keeping it apart. Curr Opin Cell Biol. 2017 Feb; 2017 Feb 23. PMID: 28236735 Webster BM, Thaller DJ, Jäger J, Ochmann SE, Borah S, Lusk CP: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing. EMBO J. 2016 Nov 15; 2016 Oct 12. PMID: 27733427 Del Viso F, Huang F, Myers J, Chalfant M, Zhang Y, Reza N, Bewersdorf J, Lusk CP, Khokha MK: Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia. Dev Cell. 2016 Sep 12; 2016 Sep 1. PMID: 27593162 Huang F, Sirinakis G, Allgeyer ES, Schroeder LK, Duim WC, Kromann EB, Phan T, Rivera-Molina FE, Myers JR, Irnov I, Lessard M, Zhang Y, Handel MA, Jacobs-Wagner C, Lusk CP, Rothman JE, Toomre D, Booth MJ, Bewersdorf J: Ultra-High Resolution 3D Imaging of Whole Cells. Cell. 2016 Aug 11; 2016 Jul 7. PMID: 27397506 King MC, Lusk CP: A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity. Curr Opin Cell Biol. 2016 Aug; 2016 Mar 28. PMID: 27031045 Lusk CP: Baby Nuclear Pores Grow Up Faster All the Time. Cell. 2016 Jul 28. PMID: 27471962 Webster BM, Lusk CP: Border Safety: Quality Control at the Nuclear Envelope. Trends Cell Biol. 2016 Jan; 2015 Oct 1. PMID: 26437591 Webster BM, Lusk CP: ESCRTs breach the nuclear border. Nucleus. 2015; 2015 May 5. PMID: 25942571 Webster BM, Colombi P, Jäger J, Lusk CP: Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Cell. 2014 Oct 9. PMID: 25303532 Lusk CP, Colombi P: Toward a consensus on the mechanism of nuclear pore complex inheritance. Nucleus. 2014 Mar-Apr; 2014 Feb 25. PMID: 24637838 Colombi P, Webster BM, Fröhlich F, Lusk CP: The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1. J Cell Biol. 2013 Oct 28. PMID: 24165936 Meinema AC, Laba JK, Hapsari RA, Otten R, Mulder FA, Kralt A, van den Bogaart G, Lusk CP, Poolman B, Veenhoff LM: Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science. 2011 Jul 1; 2011 Jun 9. PMID: 21659568 Yewdell WT, Colombi P, Makhnevych T, Lusk CP: Lumenal interactions in nuclear pore complex assembly and stability. Mol Biol Cell. 2011 Apr 15; 2011 Feb 23. PMID: 21346187