Lucas, Carrie L - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Carrie L. Lucas received her PhD from Harvard Medical School and her postdoctoral training from the National Institutes of Health, NIAID. Her laboratory investigates signaling in T cells from healthy people and patients with inherited immune disorders to dissect pathways critical for adaptive immunity. A major focus of her work has been on phosphoinositide 3-kinase (PI3K) signaling and mechanisms of disease in immunodeficient patients with activating mutations in PI3K subunits. PhD Harvard University, BBS (2011) BS UNC-Chapel Hill, Biology (2006) Postdoc NIAID/National Institutes of Health

研究领域

Immunologic Deficiency Syndromes; Immunoproliferative Disorders; Phosphatidylinositols; Protein Processing, Post-Translational; T-Lymphocytes; Signal Transduction

近期论文

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Novel PIK3CD mutations affecting N-terminal residues of p110δ cause APDS1 in humans. Takeda AJ, Zhang Y, Dornan GL, Siempelkamp BD, Jenkins ML, Matthews HF, McElwee JJ, Bi W, Seeborg FO, Su HC, Burke JE, Lucas CL. J Allergy Clin Immunol. 2017 Apr 13. pii: S0091-6749(17)30587-0. Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1. Dornan GL, Siempelkamp BD, Jenkins ML, Vadas O, Lucas CL, Burke JE. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1982-1987. doi: 10.1073/pnas.1617244114. PI3Kδ and primary immunodeficiencies. Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. Nature Reviews Immunology. 2016 Sep; doi: 10.1038/nri.2016.93. Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study. Elkaim E, Neven B, Bruneau J, Mitsui-Sekinaka K, Stanislas A, Heurtier L, Lucas CL, Matthews H, Deau MC, Sharapova S, Curtis J, Reichenbach J, Glastre C, Parry DA, Arumugakani G, McDermott E, Kilic SS, Yamashita M, Moshous D, Lamrini H, Otremba B, Gennery A, Coulter T, Quinti I, Stephan JL, Lougaris V, Brodszki N, Barlogis V, Asano T, Galicier L, Boutboul D, Nonoyama S, Cant A, Imai K, Picard C, Nejentsev S, Molina TJ, Lenardo M, Savic S, Cavazzana M, Fischer A, Durandy A, Kracker S. Journal of Allergy and Clinical Immunology. 2016 Jul;138(1):210-218.e9. Genomics of immune diseases and new therapies. Lenardo M, Lo B, Lucas CL. Annual Review of Immunology. 2016 May 20;34:121-49. Identifying genetic determinants of autoimmunity and immune dysregulation. Lucas CL, Lenardo MJ. Current Opinions in Immunology. 2015 Dec;37:28-33. Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. Lucas CL, Zhang Y, Venida A, Wang Y, Hughes J, McElwee J, Butrick M, Matthews H, Price S, Biancalana M, Wang X, Richards M, Pozos T, Barlan I, Ozen A, Rao VK, Su HC, Lenardo MJ. Journal of Experimental Medicine. 2014 Dec 15;211(13):2537-47. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G. Nature Immunology. 2014 Jan;15(1):88-97. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Bleesing JJ, Marsh RA, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ. Science. 2013 Jul 12;341(6142):186-91. Molecular basis of cell death programs in mature T cell homeostasis. Lucas CL and Lenardo MJ. Chapter 3. Cell Death: Mechanism and Disease. 2013. Springer Science. Editor: Hao Wu. LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M. Blood. 2011 May 19;117(20):5532-40. A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Fehr T, Lucas CL, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. Blood. 2010 Feb 11;115(6):1280-7. Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. Haspot F, Fehr T, Gibbons C, Zhao G, Hogan T, Honjo T, Freeman GJ, Sykes M. Blood. 2008 Sep 1;112(5):2149-55. doi: 10.1182/blood-2007-12-127449.