Louvi, Angeliki - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Angeliki Louvi (Ph.D. Columbia P&S, 1997) is Associate Professor of Neurosurgery and Neurobiology and member of the Yale Program on Neurogenetics and the Yale Interdepartmental Neuroscience PhD Program. She is currently researching the molecular mechanisms governing the development of the mammalian brain. She is particularly interested in addressing how the perturbation of basic biological mechanisms leads to clinically significant brain pathologies. Working closely with other research groups in the Yale Program on Neurogenetics, she studies the molecular and cellular mechanisms underlying cerebrovascular and structural disorders associated with specific genetic lesions. Insight into these questions will shed light on fundamental neurodevelopmental processes and provide information relevant for the design of rational therapeutic approaches. PhD Columbia College of Physicians and Surgeons (1997) BS University of Athens (1987) Postdoctoral Fellow Ecole Normale Supérieure, Paris, France and University of Chicago

研究领域

Brain; Microcephaly; Morphogenesis; Nervous System Diseases; Neurosurgery; Hemangioma, Cavernous, Central Nervous System; CADASIL; Diseases

近期论文

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Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. Nishimura, S., Bilgüvar, K., Ishigame, K., Sestan, N, Günel, M, and Louvi, A* (2015). PLOS One, (10(4):e0124295. Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Neuron, 84, 1226-1239. Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Neuron, 84, 1226-1239. Mishra-Gorur, K., Caglayan, A. O., Schaffer, A., Chabu, C., Henegariu, O., Vonhoff, F., Akgumus, G. T., Nishimura, S., Han, W., Tu, S., Baran, B., Gumus, H., Cengiz., D., Zaki, M., Hossni, H., Riviere, J.-B., Kayserili, H., Spencer, E., Rosti, R., Schroth, J., Per, H., Caglar, C., Caglar, C., Dolen, D., Baranoski, J., Kumandas, S., Minja, F., Erson-Omay, E. Z., Mane, S., Lifton, R., Xu, T., Keshishian, H., Dobyns, W., Chi, N., Sestan, N., Louvi, A., Bilguvar, K., Yasuno, K., Gleeson, J., and Günel, M. (2014). Neuron, 84, 1226-1239. Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Louvi, A.*, Nishimura, S. and Gunel, M. (2014) Development, 141, 1404-1415. Notch and disease: A growing field. Louvi, A. and Artavanis-Tsakonas, S. (2012). Semin. Cell. Dev. Biol. 23, 473-480. Recessive laminin γ3 mutations cause malformations of occipital cortical development. Barak, T.*, Kwan, K. Y.*, Louvi, A., Demirbilek, V., Saygi, S., Tüysüz, B., Choi, M., Boyaci, H., Doerschner, K., Zhu, Y., Kaymakçalan, H., Yilmaz, S., Bakircioglu, M., Çaglayan, A. O., Öztürk, A. K., Yasuno, K., Brunken, W. J., Atalar, E., Yalçinkaya, C., Dinçer, A., Bronen, R. A., Mane, S., Özçelik, T., Lifton, R. P., Šestan, N., Bilgüvar, K., and Günel, M. (2011). Nat. Genet. 43, 590-594. Hypomorphic Notch 3 alleles link Notch signalling to ischemic cerebral small-vessel disease. Arboleda-Velasquez, J., Manent, J., Lee J. H., Tikka, S., Ospina, C., Vanderburg, C. R., Frosch, M.P., Rodriguez-Falcon, M., Villen, J., Gygi, S., Lopera, F., Kalimo, H., Moskowitz, M. A., Ayata, C., Louvi, A.*, and Artavanis-Tsakonas, S.* (2011). Proc. Natl. Acad. Sci. USA. 108, E128-135. Cilia in the CNS: the Quiet Organelle Takes Center Stage. Louvi, A. and Grove, E.A. (2011). Neuron 69, 1046-1060. Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Louvi, A.*, Chen, L., Two, A. M., Zhang, H., Min, W., and Günel, M.* (2011). Proc. Natl. Acad. Sci. USA. 108, 3737-3742. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Bilgüvar, K*., Oztürk, A. K.*, Louvi, A., Kwan, K. Y., Choi, M., Tatli, B., Yalnizoglu, D., Tüysüz, B., Caglayan, A. O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioglu, M., Yasuno, K., Ho, W., Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M. H., Bronen, R. A., Koçer, N., Per, H., Mane, S., Pamir, M. N., Yalçınkaya, C., Kumandaş, S., Topçu, M., Ozmen, M., Sestan, N., Lifton, R. P., State, M. W., Günel, M. (2010). Nature 467, 207-210. Apoptotic functions of PDCD10, the gene mutated in cerebral cavernous malformation 3. Chen, L., Tanriover, G., Yano, H., Friedlander, R., Louvi, A. and Günel, M. (2009). Stroke 40, 1474-1481. Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. Stillman, A.*, Krsnik, Z.*, Sun, J., Rasin, M.-R., State, M. W., Sestan, N., and Louvi, A. (2009). J. Comp. Neurol., 513:21-37. The derivatives of the Wnt3a lineage in the central nervous system. Louvi, A.*, Yoshida, M. and Grove, E.A. (2007). J. Comp. Neurol. 504, 550-569. Notch signalling in vertebrate neural development.