Lombroso, Paul J - Yale University - Biological & Biomedical Sciences

个人简介

MD Albert Einstein College (1975) BA Harvard College (1972) NIMH/Merck Postdoctoral Fellow Child Study Center, Yale University Research Associate Laboratory of Cellular and Molecular Neuroscience, The Rockefeller University Chief Chief, Child and Adolescent Outpatient Clinic, St. Vincent's Hospital and Medical Center of New York Resident Bronx Mental Health Center Fellow Beth Israel Hospital Board Certification AB of Psychiatry & Neurology, Psychiatry (1980) Board Certification AB of Psychiatry & Neurology, Child & Adolescent Psychiatry (1987)

研究领域

Adolescent Psychiatry; Alzheimer Disease; Child Psychiatry; Fragile X Syndrome; Neuropharmacology; Neurosciences; Parkinson Disease; Psychiatry; Schizophrenia; Protein Tyrosine Phosphatases, Non-Receptor

近期论文

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Inhibitors of the tyrosine phosphatase STEP reverse cognitive deficits in a mouse model of Alzheimer’s disease. Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Onomenyi C, Foscue E, Anderson GM, Gressack J, Cuny GD, Glicksman MA, Greengard P, Lam T, Nairn AC, Tautz L, Ellman JA, Lombroso PJ (2014) Inhibitors of the tyrosine phosphatase STEP reverse cognitive deficits in a mouse model of Alzheimer’s disease. PLoS Biology 12(8):e1001923. doi: 10.1371/journal.pbio.1001923. PMCID4122355 Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Chiodi V, Mallozzi C, Fan Chen J, Ferrante A, Lombroso PJ, Di Stasi AM, Domenici MR, Popoli P (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 39:569-578 PMCID3895235 Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase. Baguley TD, Xu HC, Chatterjee M, Lombroso PJ, Ellman J (2013) Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase. J Med Chem 56:7636-7650. PMCID in progress. Neuroprotective role of STEP, a brain-enriched tyrosine phosphatase, in focal cerebral ischemia. Deb I, Manhas N, Poddar R, Allan AM, Rajagopal S, Lombroso PJ, Rosenberg GA, Jalil EC, Paul S (2013) Neuroprotective role of STEP, a brain-enriched tyrosine phosphatase, in focal cerebral ischemia. J Neuroscience 33:17814-17826. PMCID3818554. Therapeutic implications for STriatal-Enriched protein tyrosine Phosphatase (STEP) in neuropsychiatric disorders. Goebel-Goody SM, Baum M, Paspalas C, Carty NC, Fernandez S, Kurup P, Lombroso PJ (2012) Therapeutic implications for STriatal-Enriched protein tyrosine Phosphatase (STEP) in neuropsychiatric disorders. Pharmacological Reviews 64:65-87. PMCID3250079. The tyrosine phosphatase STEP: Implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Carty NC, Xu J, Kurup P, Goebel-Goody SM, Brouillette J, Austin DR, Yuan P, Chen P, Chen G, Correa PR, Pittenger C, Lombroso PJ (2012) The tyrosine phosphatase STEP: Implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Translational Psychiatry 2:e137 doi:10.1038/tp.2012. 63. PMCID3410627. Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington’s disease mouse model. Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA (2012) Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington’s disease mouse model. Human Molecular Genetics 21:3739-52 PMCID3412376 Striatal-Enriched protein tyrosine Phosphatase (STEP) knockout mice have enhanced hippocampal memory. Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ (2011) Striatal-Enriched protein tyrosine Phosphatase (STEP) knockout mice have enhanced hippocampal memory. Eur J Neurosci. 33:2288-2298. PMCID3118976. STEP expression and activity in Huntington’s disease-a STEP in the resistance to excitotoxicity. Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas J, Lombroso PJ, Alberch J, Pérez-Navarro E (2011) STEP expression and activity in Huntington’s disease-a STEP in the resistance to excitotoxicity. J Neuroscience 31:8150-8162. PMCID3472648. Genetic reduction of STEP reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease. Zhang YF, Kurup P, Xu J, Carty N, Fernandez S, Nygaard HB, Pittenger C, Greengard P, Strittmatter S, Nairn AC and Lombroso PJ (2010) Genetic reduction of STEP reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease. PNAS. Abeta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61. Kurup P, Zhang YF, Xu J, Venkitaramani DV, Haroutunian V, Nairn A, Lombroso PJ (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neuroscience 30:5948-5957. Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. Xu J, Kurup P, Zhang YF, Goebel-Goody S, Wu P, Hawasli AH, Baum M, Bibb J, Lombroso PJ (2009) Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neuroscience 29:9330-9343. The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.