Lolis, Elias - Yale University - Biological & Biomedical Sciences

个人简介

Elias Lolis received his PhD in 1989 from MIT in Chemistry/Biochemistry studying the three-dimensional structure and mechanism of triosephosphate isomerase. He was a postdoctoral associate at the Laboratory of Medical Biochemistry at Rockefeller University studying the functional interaction between advanced glycation end products (AGEs) and the immune system. He joined the Yale faculty in 1991 as an Assistant Professor focusing on the structure, mechanism, and inhibition of chemokines, macrophage migration inhibitory factor (MIF), and their receptors. He has received a Pharmaceutical Manufacturers Association Faculty Development Award in Basic Pharmacology, the Donaghue Young Investigator Award, and the GlaxoWellcome Award in Drug Discovery. PhD Massachusetts Institute of Technology, Biochemistry/Chemistry (1989) BA Columbia College (1984) Postdoc Rockefeller University

研究领域

Education; Immune System Diseases; Inflammation; Neoplasms; Parasitic Diseases; Pharmacology; Crystallography, X-Ray; Enzymes and Coenzymes; High-Throughput Screening Assays

近期论文

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Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE. J Biol Chem. 2016 Jul 22;291(30):15881-95. doi: 10.1074/jbc.M116.717751. An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors. J Med Chem. 2014 Oct 23;57(20):8652-6. doi: 10.1021/jm501168q. Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. FASEB J. 2014 Nov;28(11):4961-71. doi: 10.1096/fj.14-256636. Structural insight into the evolution of a new chemokine family from zebrafish. Proteins. 2014 May;82(5):708-16. doi: 10.1002/prot.24380. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10994-9. doi: 10.1073/pnas.1221817110. Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7. Biochem Pharmacol. 2013 Nov 1;86(9):1263-71. doi: 10.1016/j.bcp.2013.08.019. Epub 2013 Aug 22. Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, Shachar I: CD74 is a novel transcription regulator. Proc Natl Acad Sci U S A. 2017 Jan 17; 2016 Dec 28. PMID: 28031488 Meza-Romero R, Benedek G, Jordan K, Leng L, Pantouris G, Lolis E, Bucala R, Vandenbark AA: Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74. Cytokine. 2016 Dec; 2016 Aug 27. PMID: 27573366 Rajasekaran D, Gröning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J: Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE. J Biol Chem. 2016 Jul 22; 2016 May 19. PMID: 27226569 Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE: Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail. Biochem J. 2016 Feb 1; 2015 Nov 16. PMID: 26574436 Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Averdunk L, Sun Y, Rossaint R, Lue H, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J: Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients. Antioxid Redox Signal. 2015 Oct 10; 2015 Aug 11. PMID: 26234719 Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem Biol. 2015 Sep 17; 2015 Sep 10. PMID: 26364929 Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME: Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties. J Biol Chem. 2015 Apr 17; 2015 Feb 25. PMID: 25716316 Rajasekaran D, Zierow S, Syed M, Bucala R, Bhandari V, Lolis EJ: Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. FASEB J. 2014 Nov; 2014 Jul 11. PMID: 25016026 Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ: Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors. J Med Chem. 2014 Oct 23; 2014 Oct 8. PMID: 25268646 Ioannou K, Cheng KF, Crichlow GV, Birmpilis AI, Lolis EJ, Tsitsilonis OE, Al-Abed Y: ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. Int J Oncol. 2014 Oct; 2014 Jul 22. PMID: 25050663 Rajasekaran D, Fan C, Meng W, Pflugrath JW, Lolis EJ: Structural insight into the evolution of a new chemokine family from zebrafish. Proteins. 2014 May; 2013 Dec 14. PMID: 23900850 Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ: MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci U S A. 2013 Jul 2; 2013 Jun 17. PMID: 23776208 Crichlow GV, Fan C, Keeler C, Hodsdon M, Lolis EJ: Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry. 2012 Sep 25; 2012 Sep 11. PMID: 22931430 Sun T, Holowka T, Song Y, Zierow S, Leng L, Chen Y, Xiong H, Griffith J, Nouraie M, Thuma PE, Lolis E, Janse CJ, Gordeuk VR, Augustijn K, Bucala R: A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proc Natl Acad Sci U S A. 2012 Jul 31; 2012 Jul 9. PMID: 22778413 Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME, Lolis EJ: A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry. 2012 Jul 17; 2012 Jul 2. PMID: 22686371 Cho Y, Vermeire JJ, Merkel JS, Leng L, Du X, Bucala R, Cappello M, Lolis E: Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chem Biol. 2011 Sep 23. PMID: 21944748 Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, Bucala R: The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A. 2011 Aug 23; 2011 Aug 4. PMID: 21817065 Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Åkerström G, Wang W, Carling T, Lifton RP: K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011 Feb 11. PMID: 21311022