Lindenbach, Brett David - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Lindenbach received his B.S. from the University of Illinois, and Ph.D. from Washington University in St. Louis, where he studied the replication of RNA viruses. He completed postdoctoral studies with Dr. Paul Ahlquist at the HHMI/University of Wisconsin and with Dr. Charlie Rice at The Rockefeller University, where he developed the first robust cell culture model of hepatitis C virus. Dr. Lindenbach has been a member of the Yale faculty since 2006. PhD Washington University School of Medicine, Immunology (1999) PhD Washington University School of Medicine (1999) BS University of Illinois (1990) Research Associate The Rockefeller University Postdoctoral Fellow HHMI/University of Wisconsin

研究领域

Arbovirus Infections; Biochemistry; Biology; Biotechnology; Genetic Techniques; Hepatitis, Viral, Human; Hepatitis C; Liver Diseases; Microscopy; RNA; RNA Virus Infections; Viruses

近期论文

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Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins. Kazakov T, Yang F, Ramanathan HN, Kohlway A, Diamond MS, Lindenbach BD (2015) PLoS Pathogens 11(4):e1004817. Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD (2014) "." J. Virol. 88(1):628-42. The ins and outs of hepatitis C virus entry and assembly. Lindenbach BD, Rice CM. (2013) Nature Reviews Microbiology. 2013 Oct;11(10):688-700. Structural Insights into RNA Recognition by RIG-I. Luo D., Ding S.C., Vela A., Kohlway A., Lindenbach B.D., Pyle A.M. (2011). Cell 147(2):409-22. Trafficking of Hepatitis C Virus Core Protein During Virus Particle Assembly. Counihan N.A., Rawlinson S.M., Lindenbach B.D. (2011) PLoS Pathogens 7(10): e1002302. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. Stapleford K.A., Lindenbach B.D. (2011) J Virol. 85(4):1706-17. The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. Phan T., Kohlway A., Dimberu P., Pyle A.M., Lindenbach B.D. (2011) J Virol. 85(3):1193-204. Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. Phan T., Beran R.K., Peters C., Lorenz I.C., Lindenbach B.D. (2009). J. Virol. (83):8379-95. Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Lindenbach, B.D., et al. (2006). Proc. Natl. Acad. Sci. (USA) 103:3805-3809. Complete replication of hepatitis C virus in cell culture. Lindenbach, B.D., et al. (2005). Science 309:623-626. Flaviviridae: the viruses and their replication. Lindenbach, B.D., Murray, C.L., Thiel, H.-J., Rice, C.M. (2007) Fields Virology, 5th Ed. Unravelling hepatitis C virus replication from genome to function. Lindenbach BD, Rice CM. (2005) Nature 436, 933-938. The coding region of the HCV genome contains a network of regulatory RNA structures. Pirakitikulr N. Kohlway A., Lindenbach B.D., and A.M. Pyle. Molecular Cell 2016, 62(1):111-20.