LaMotte, Robert H - Yale University - Biological & Biomedical Sciences

个人简介

Our laboratory uses the methods of single-cell electrophysiology (in vitro and in vivo) and sensory psychophysics to study the peripheral neural mechanisms of pain and itch in humans and animals. PhD Kansas State University (1968) Fellow Kansas State University Fellow Johns Hopkins University

研究领域

Anesthesiology; Nervous System; Neurochemistry; Neurons; Neurophysiology; Pain; Electrophysiological Processes; Nociceptive Pain

近期论文

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Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. 2015. J Pain 16(8):741-749 CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. 2015. Pain 156(9):1737-1746 Enhanced excitability of MrgprA3-positive and MrgprD-positive nociceptors in a model of inflammatory itch and pain Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Brain 137(Pt 4):1039-1050 A subpopulation of nociceptors specifically linked to itch. Han, L., Ma, C., Liu, Q., Weng, H.J., Cui, Y., Tang, Z., Kim, Y., Nie, H., Qu, L., Patel, K.N., Li, Z., McNeil, B., He, S., Guan, Y., Xiao, B., LaMotte, R.H. & Dong, X. (2012). A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 16(2), 174-182. PMCID: PMC3557753 In-vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. Ma C, Nie H, Gu Q, Sikand P, LaMotte RH. In-vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. J. Neurophysiol 107(1):357-63, 2012. Behavioral differentiation between itch and pain in mouse Shimada SG and LaMotte RH (2008) Behavioral differentiation between itch and pain in mouse, Pain, 139, 681, Published Qu L, Fu K, Shimada SG, LaMotte RH: Cl- channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. J Neurophysiol. 2017 Apr 26; 2017 Apr 26. PMID: 28446581 LaMotte RH: Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Adv Exp Med Biol. 2016. PMID: 26900060 Song XJ, LaMotte RH, Xie Z: Regulation of Cytokines in Cancer Pain. Mediators Inflamm. 2016; 2016 Mar 20. PMID: 27087747 Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH: Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLoS One. 2015; 2015 Sep 10. PMID: 26356638 Qu L, Fu K, Yang J, Shimada SG, LaMotte RH: CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis. Pain. 2015 Sep. PMID: 25932692 Pall PS, Hurwitz OE, King BA, LaMotte RH: Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis. J Pain. 2015 Aug; 2015 May 19. PMID: 26002605 Fu K, Qu L, Shimada SG, Nie H, LaMotte RH: Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity. Neurosci Lett. 2014 Sep 5; 2014 Apr 3. PMID: 24704378 Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH: Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain. 2014 Apr; 2014 Feb 18. PMID: 24549959 LaMotte RH, Dong X, Ringkamp M: Sensory neurons and circuits mediating itch. Nat Rev Neurosci. 2014 Jan. PMID: 24356071 Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, Lamotte RH, Park IH, Snyder MP, Mason CE, Weissman SM: Two methods for full-length RNA sequencing for low quantities of cells and single cells. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 24. PMID: 23267071 Qu L, Li Y, Pan X, Zhang P, LaMotte RH, Ma C: Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons. J Neurosci. 2012 Jul 11. PMID: 22787041 Fan N, Donnelly DF, LaMotte RH: Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons. J Neurophysiol. 2011 Dec; 2011 Sep 14. PMID: 21917996 Sikand P, Shimada SG, Green BG, LaMotte RH: Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain. 2011 Nov; 2011 Jul 29. PMID: 21802851