Kwan, Alex - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Kwan received a B.A.Sc. in Engineering Physics from Simon Fraser University and a Ph.D. in Applied Physics from Cornell University. At Cornell, he developed nonlinear optical microscopy methods in the laboratory of Watt Webb. In 2009, he went to the University of California, Berkeley to work in the laboratory of Yang Dan, where he studied cortical GABAergic interneurons. He joined the Yale School of Medicine faculty in 2013. Research in the Kwan lab focuses on the mouse prefrontal cortex. We are interested in how circuit mechanisms allow flexibility in voluntary behaviors, and how network dysfunctions underlie cognitive deficits in mental illnesses. Our expertise lies in developing and applying optical methods to record and control neural activity in behaving mice. PhD Cornell University (2009) MS Cornell University (2007) BS Simon Fraser University (2003) Postdoctoral University of California, Berkeley (2009 - 2013)

研究领域

Decision Making; Depressive Disorder; Electrophysiology; Microscopy, Fluorescence; Schizophrenia; Prefrontal Cortex; Executive Function

近期论文

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Secondary motor cortex: where 'sensory' meets 'motor' in the rodent frontal cortex Barthas F, and Kwan AC. Secondary motor cortex: where 'sensory' meets 'motor' in the rodent frontal cortex. Trends in Neurosciences, 40, 181-193 (2017). Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior. Siniscalchi MJ, Phoumthipphavong V, Ali F, Lozano M, and Kwan AC. Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior. Nature Neuroscience, 19, 1234-1242 (2016). Longitudinal effects of ketamine on dendritic architecture in vivo in the mouse medial frontal cortex. Phoumthipphavong V, Barthas F, Hassett S, and Kwan AC. Longitudinal effects of ketamine on dendritic architecture in vivo in the mouse medial frontal cortex. eNeuro, 3(2):0133-15.2016 (2016). Barthas F, Kwan AC: Secondary Motor Cortex: Where 'Sensory' Meets 'Motor' in the Rodent Frontal Cortex. Trends Neurosci. 2017 Mar; 2016 Dec 22. PMID: 28012708 Siniscalchi MJ, Phoumthipphavong V, Ali F, Lozano M, Kwan AC: Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior. Nat Neurosci. 2016 Sep; 2016 Jul 11. PMID: 27399844 Phoumthipphavong V, Barthas F, Hassett S, Kwan AC: Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex. eNeuro. 2016 Mar-Apr; 2016 Apr 4. PMID: 27066532 Lee SH, Kwan AC, Dan Y: Interneuron subtypes and orientation tuning. Nature. 2014 Apr 3. PMID: 24695313 Pinto L, Goard MJ, Estandian D, Xu M, Kwan AC, Lee SH, Harrison TC, Feng G, Dan Y: Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat Neurosci. 2013 Dec; 2013 Oct 27. PMID: 24162654 Kwan AC, Dan Y: Dissection of cortical microcircuits by single-neuron stimulation in vivo. Curr Biol. 2012 Aug 21; 2012 Jun 28. PMID: 22748320 Lee SH, Kwan AC, Zhang S, Phoumthipphavong V, Flannery JG, Masmanidis SC, Taniguchi H, Huang ZJ, Zhang F, Boyden ES, Deisseroth K, Dan Y: Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature. 2012 Aug 16. PMID: 22878719 Yuen D, Wu X, Kwan AC, Ledue J, Zhang H, Ecoiffier T, Pytowski B, Chen L: Live imaging of newly formed lymphatic vessels in the cornea. Cell Res. 2011 Dec; 2011 Nov 15. PMID: 22083511 Kadiri LR, Kwan AC, Webb WW, Harris-Warrick RM: Dopamine-induced oscillations of the pyloric pacemaker neuron rely on release of calcium from intracellular stores. J Neurophysiol. 2011 Sep; 2011 Jun 15. PMID: 21676929 Kwan AC, Dietz SB, Zhong G, Harris-Warrick RM, Webb WW: Spatiotemporal dynamics of rhythmic spinal interneurons measured with two-photon calcium imaging and coherence analysis. J Neurophysiol. 2010 Dec; 2010 Sep 22. PMID: 20861442 Kwan AC: Toward reconstructing spike trains from large-scale calcium imaging data. HFSP J. 2010 Feb; 2010 Jan 22. PMID: 20676302 Zhong G, Droho S, Crone SA, Dietz S, Kwan AC, Webb WW, Sharma K, Harris-Warrick RM: Electrophysiological characterization of V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord. J Neurosci. 2010 Jan 6. PMID: 20053899 Kwan AC, Dietz SB, Webb WW, Harris-Warrick RM: Activity of Hb9 interneurons during fictive locomotion in mouse spinal cord. J Neurosci. 2009 Sep 16. PMID: 19759307 Kwan AC, Duff K, Gouras GK, Webb WW: Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation. Opt Express. 2009 Mar 2. PMID: 19259208 Kwan AC: What can population calcium imaging tell us about neural circuits? J Neurophysiol. 2008 Dec; 2008 Oct 1. PMID: 18829844 Kwan AC, Dombeck DA, Webb WW: Polarized microtubule arrays in apical dendrites and axons. Proc Natl Acad Sci U S A. 2008 Aug 12; 2008 Aug 5. PMID: 18682556