Krystal, John H. - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Krystal is a leading expert in the areas of alcoholism, schizophrenia, and post-traumatic stress disorder. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and to develop novel treatments for these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients. He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, and the Karolinska Institutet. He previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, the NIMH Board of Scientific Counselors (chair, 2005-2007), and American College of Neuropsychopharmacology (president, 2012). Currently, he is president of the International College of Neuropsychopharmacology, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.212). MD Yale University (1984) BA University of Chicago, Behavioral Sciences (1980) Residency Yale University School of Medicine

研究领域

Alcoholism; Drug Therapy; Genetics; Neurobiology; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans; Neuroimaging

近期论文

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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016 Mar;22(3):238-49. doi: 10.1038/nm.4050. PubMed PMID: 26937618. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E219-28. doi: 10.1073/pnas.1508436113. Epub 2015 Dec 23. PubMed PMID: 26699491; PubMed Central PMCID: PMC4720350. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 1. pii: 201413947. [Epub ahead of print] PubMed PMID: 25453062. Computational Psychiatry. Wang XJ, Krystal JH. Computational Psychiatry. Neuron. 2014 Nov 5;84(3):638-654. doi: 10.1016/j.neuron.2014.10.018. Epub 2014 Nov 5. Review. PubMed PMID: 25442941; PubMed Central PMCID: PMC4255477. Psychiatric Disorders: Diagnosis to Therapy. Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell. 2014 Mar 27;157(1):201-214. doi: 10.1016/j.cell.2014.02.042. Review. PubMed PMID: 24679536. Increased brain uptake and oxidation of acetate in heavy drinkers. Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. J Clin Invest. 2013 Apr;123(4):1605-14. doi: 10.1172/JCI65153. Epub 2013 Mar 8. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ,Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH*, Corlett PR*. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16720-5. doi: 10.1073/pnas.1208494109. Epub 2012 Sep 25. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C; Veterans Affairs Cooperative Study No. 504 Group. JAMA. 2011 Aug 3;306(5):493-502. doi: 10.1001/jama.2011.1080. Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD: Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biol Psychiatry. 2017 May 15; 2017 Jan 13. PMID: 28434616 Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A: Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biol Psychiatry. 2017 May 15; 2017 Mar 14. PMID: 28434615 Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology. 2017 May 11; 2017 May 11. PMID: 28492279 Abdallah CG, Southwick SM, Krystal JH: Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics. Neurosci Lett. 2017 May 10. PMID: 28478864 Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG: Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neurosci Lett. 2017 May 10; 2016 Dec 1. PMID: 27916636 Steine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Grønli J, Pallesen S: Posttraumatic symptom profiles among adult survivors of childhood sexual abuse: A longitudinal study. Child Abuse Negl. 2017 May; 2017 Mar 19. PMID: 28327414 Wrocklage KM, Averill LA, Cobb Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG: Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. Eur Neuropsychopharmacol. 2017 May; 2017 Mar 6. PMID: 28279623 Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A: Computational Psychiatry and the Challenge of Schizophrenia. Schizophr Bull. 2017 May 1. PMID: 28338845 Goldenberg MN, Krystal JH: Undergraduate Neuroscience Majors: A Missed Opportunity for Psychiatry Workforce Development. Acad Psychiatry. 2017 Apr; 2017 Feb 10. PMID: 28188505