Kriegel, Martin Alexander - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Kriegel is an Assistant Professor of Immunobiology and of Medicine (Rheumatology) at Yale School of Medicine. In 2001, he received his MD/PhD equivalent at the Friedrich-Alexander University of Erlangen, Germany, followed by the German Medical Licensure in 2002. From 2003 to 2006, he performed postdoctoral training in immunology at Yale with Dr. Richard Flavell before completing a medicine residency and rheumatology fellowship at Harvard (Beth Israel Deaconess Medical Center and Brigham & Women’s Hospital). During this time, he performed additional postdoctoral research at Harvard Medical School with Drs. Diane Mathis and Christophe Benoist. Dr. Kriegel returned to Yale in 2012 as a tenure-track faculty member in the Department of Immunobiology. He is also a board-certified rheumatologist at Yale-New Haven Hospital and maintains a specialty clinic for antiphospholipid syndrome. His NIH-funded laboratory explores host-microbiota interactions in immune diseases by combining human microbiome studies with mechanistic work, which includes utilization of gnotobiotic models. He was an Emmy-Noether Scholar of the German Research Foundation, an Arthritis National Research Foundation Scholar, an awardee of the Lupus Research Institute, the Arthritis Foundation, and the Rheumatology Research Foundation. He serves as an Advisory Editor for Arthritis & Rheumatology and is a member of the American Association for the Advancement of Science, the German and American Association of Immunologists, the American College of Rheumatology, and the Society for Mucosal Immunology. PhD Friedrich-Alexander University of Erlangen-Nurn (2001) MD Friedrich-Alexander University of Erlangen (2000) Rheumatology Fellowship Brigham and Women's Hospital, Harvard Medical School Residency Beth Israel Deaconess Medical Center, Harvard Medical School Postdoctoral Fellowship Yale University School of Medicine Clinical Fellowship University Hospital, Erlangen, Germany Board Certification AB of Internal Medicine, Internal Medicine (2009) Board Certification AB of Internal Medicine, Rheumatology (2011)

研究领域

Bacteria; Immune Tolerance; Immune System Diseases; Lymphocyte Activation; Autoimmunity; Immunity, Mucosal; Host-Pathogen Interactions; Biological Processes

近期论文

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Autoimmune host-microbiota interactions at barrier sites and beyond. Ruff WE, Kriegel MA. Autoimmune host-microbiota interactions at barrier sites and beyond. Trends in Mol Med 2015; 21(4):233-244 Vieira SM, Pagovich OE, Kriegel MA. Diet, Microbiota and Autoimmune Diseases. Lupus 2014;23(6):518-26. Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells Kriegel MA*, Rathinam C, Flavell RA*. Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells. Proc Natl Acad Sci U S A 2012; 109(9):3457-3462. (*corresponding authors) Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice. Kriegel MA, Sefik E, Hill JA, Wu H-J, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice. Proc Natl Acad Sci U S A 2011; 108(28):11548-53. E3 Ubiquitin Ligase GRAIL Controls Primary T Cell Activation and Oral Tolerance. Kriegel MA*, Rathinam C*, Flavell RA. E3 Ubiquitin Ligase GRAIL Controls Primary T Cell Activation and Oral Tolerance. Proc Natl Acad Sci U S A 2009;106(39) 16770-5. (*equal contribution) Defective Suppressor Function of Human CD4+ CD25+ Regulatory T cells in Autoimmune Polyglandular Syndrome Type II. Kriegel MA*, Lohmann T, Gabler C, Blank N, Kaldern JR, Lorenz HM. Defective Suppressor Function of Human CD4+ CD25+ Regulatory T cells in Autoimmune Polyglandular Syndrome Type II. J Exp Med 2004;199(9):1285-91. (*corresponding author) Kriegel MA: Self or non-self? The multifaceted role of the microbiota in immune-mediated diseases. Clin Immunol. 2015 Aug; 2015 May 21. PMID: 26003838 Ruff WE, Kriegel MA: Autoimmune host-microbiota interactions at barrier sites and beyond. Trends Mol Med. 2015 Apr; 2015 Mar 11. PMID: 25771098 Ruff WE, Vieira SM, Kriegel MA: The role of the gut microbiota in the pathogenesis of antiphospholipid syndrome. Curr Rheumatol Rep. 2015 Jan. PMID: 25475595 Tiniakou E, Costenbader KH, Kriegel MA: Sex-specific environmental influences on the development of autoimmune diseases. Clin Immunol. 2013 Nov; 2013 Feb 28. PMID: 23507400 Kriegel MA, Rathinam C, Flavell RA: Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2012 Feb 28; 2012 Feb 10. PMID: 22328150 Kriegel MA, Rathinam C, Flavell RA: E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proc Natl Acad Sci U S A. 2009 Sep 29; 2009 Sep 17. PMID: 19805371 Kriegel MA, Tretter T, Blank N, Schiller M, Gabler C, Winkler S, Kalden JR, Lorenz HM: Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells. Immunology. 2006 Sep; 2006 Jun 6. PMID: 16762027 Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA: Transforming growth factor-beta: recent advances on its role in immune tolerance. Curr Rheumatol Rep. 2006 Apr. PMID: 16569373