Krause, Diane S - Yale University - Biological & Biomedical Sciences

个人简介

Diane Krause MD, PhD is Professor of Laboratory Medicine, Pathology and Cell Biology at Yale University; Associate Director of the Yale Stem Cell Center; and Director of the Clinical Cell Processing Laboratory. She received an Sc.B. degree in Biology from Brown University, and an MD and PhD degree from the University of Pennsylvania. After completing a residency in Clinical Pathology at the University of Pennsylvania, she performed post-doctoral studies at Johns Hopkins University. MD University of Pennsylvania (1990) PhD University of Pennsylvania (1990) Fellow Johns Hopkins Hospital Resident Hospital of the University of Pennsylvania Board Certification AB of Pathology, Clinical Pathology (1994)

研究领域

Cell Biology; Hematology; Leukemia; Pathology; Stem Cells; Medical Laboratory Science; Gene Expression; Bone Marrow Transplantation

近期论文

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URL for full list of published work in publicly available database, My Bibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/diane.krause.1/bibliography/40319867/public/?sort=date&direction=ascending Adult Human Megakaryocyte-Erythroid Progenitors are in the CD34+CD38mid Fraction. Sanada C, Xavier-Ferrucio J, Lu Y-C, Min E, Zhang P-X, Zou S, Kang E, Zhang M, Zerafati G, Gallagher PG, Krause DS. Adult Human Megakaryocyte-Erythroid Progenitors are in the CD34+CD38mid Fraction. Blood. 2016 Aug 18;128(7):923-33. doi: 10.1182/blood-2016-01-693705. Epub 2016 Jun 6. Non-stochastic reprogramming from a privileged somatic cell state. Guo S, Zi X, Schulz V, Cheng J, Zhong M, Koochaki SHJ, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J. Non-stochastic reprogramming from a privileged somatic cell state. Cell, 2014. Role of RhoA specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Gao,Y, Smith E, Ker E, Campbell P, Cheng E, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Developmental Cell 22:573-84, 2012. PMID: 22387001 Serum Response Factor is an essential transcription factor in megakaryocytic maturation. Halene S, Gao Y, Hahn K, Massaro S, Italiano JE, Lin S, Kupfer GM, Krause DS. Serum Response Factor is an essential transcription factor in megakaryocytic maturation. Blood 116:1942-1950, 2010. PMID: 20525922. Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Kassmer SH, Jin H, Zhang P-X, Bruscia EM, Heydari K, Lee, J-H, Kim CF, Krause DS. Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Stem Cells 2013, May 16. PMID: 23681901 Non-hematopoietic cells are the primary source of bone marrow derived lung epithelial cells. Kassmer SH, Bruscia EM, Zhang P, Krause DS. Non-hematopoietic cells are the primary source of bone marrow derived lung epithelial cells. Stem Cells 30: 491-499, 2012. PMID: 22162244. Megakaryoblastic leukemia 1 (MKL1) promotes megakaryocytic differentiation. Cheng E, Luo Q, Renda MJ, Troy JA, Wang L, Tuck D, Schulz V, Mane S, Berliner N, Sun Y, Morris SW, Krause DS. Megakaryoblastic leukemia 1 (MKL1) promotes megakaryocytic differentiation. Blood 2009 113:2826-34. Epub 2009 Jan 9. PMID: 19136660. Rbm15 modulates notch-induced transcriptional activation and affects myeloid differentiation. Ma, X., et al. (2007). Rbm15 modulates notch-induced transcriptional activation and affects myeloid differentiation. MCB 27:3056-64. de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA: Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017 Mar; 2017 Jan 23. PMID: 28112737 Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM: In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016 Oct 26; 2016 Oct 26. PMID: 27782131 Zou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferrucio J, Zhang PX, Hwa J, Min W, Krause DS: Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation. Thromb Haemost. 2016 Aug 30; 2016 Jun 23. PMID: 27345948 Sanada C, Xavier-Ferrucio J, Lu YC, Min E, Zhang PX, Zou S, Kang E, Zhang M, Zerafati G, Gallagher PG, Krause DS: Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood. 2016 Aug 18; 2016 Jun 6. PMID: 27268089 Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y: ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight. 2016 Jul 7. PMID: 27525311 Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME: Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259 Krause DS: An oxidase road to platelet adhesion. Blood. 2016 Mar 17. PMID: 26989190 Chae WJ, Ehrlich AK, Chan PY, Teixeira AM, Henegariu O, Hao L, Shin JH, Park JH, Tang WH, Kim ST, Maher SE, Goldsmith-Pestana K, Shan P, Hwa J, Lee PJ, Krause DS, Rothlin CV, McMahon-Pratt D, Bothwell AL: The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. Immunity. 2016 Feb 16; 2016 Feb 9. PMID: 26872695