Koelle, Michael R - Yale University - Biological & Biomedical Sciences

个人简介

1986 BS, Biology, University of Washington 1986 BS, Math, University of Washington 1992 PhD, Biochemistry, Stanford University 1992-1996 Postdoctoral Researcher, MIT 1996-2001 Assistant Professor, Yale University 2001- Associate Professor, Yale University PhD Stanford University (1992)

研究领域

Biochemistry; Biophysics; Molecular Biology; Neurobiology; Serotonin; Caenorhabditis elegans; Neurotransmitter Agents; RGS Proteins

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. Bellemer, A., Hirata, T., Romer,o M.F., and Koelle, M.R. (2011). Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. EMBO J. 30, 1852-1863. AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G alpha(o) Hofler, C., and Koelle, M.R. (2011). AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G alpha(o). J. Neurosci. 31, 11553-11562. RSBP-1 is a membrane targeting subunit required by the Gaq-specific but not the Gao-specific R7 Regulator of G protein Signaling in Caenorhabditis elegans. Porter, M.Y., and Koelle, M.R. (2009). RSBP-1 is a membrane targeting subunit required by the Gaq-specific but not the Gao-specific R7 Regulator of G protein Signaling in Caenorhabditis elegans. Mol. Biol. Cell, in press. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in C. Tanis, J.E., Bellemer, A., Moresco, J.J., Forbush, B., and Koelle, M.R. (2009). The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in C. elegans. J. Neurosci. 29, 9943-9954. A specific subset of TRPV channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Jose, A.M., Bany, I.A., Chase, D.L., and Koelle, M.R. (2007). A specific subset of TRPV channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Genetics 175:93-105. A specific subset of TRPV channel subunits function as mixed heteromers to promote neurotransmitter release. Jose, A.M., Bany, I.A., Chase, D.L. and Koelle, M.R. A specific subset of TRPV channel subunits function as mixed heteromers to promote neurotransmitter release. Submitted (2006) Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. Palmitessa, A., Hess, H.A., Bany, I.A., Kim, Y.M., Koelle, M.R. and Benovic, J.L. Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. J. Biol. Chem. 280, 24649-24662 (2005) Domains, amino acid residues, and new isoforms of C. elegans diacyglycerol kinase DGK-1 important for terminating diacylglycerol signaling in vivo. Jose, A.M. and Koelle, M.R. Domains, amino acid residues, and new isoforms of C. elegans diacyglycerol kinase DGK-1 important for terminating diacylglycerol signaling in vivo. J. Biol. Chem. 280, 2730-2736 (2005) RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. Hess, H.A., Röper, J.C., Grill, S.W., and Koelle, M.R. (2004). RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell 119:209-218. Ghosh DD, Sanders T, Hong S, McCurdy LY, Chase DL, Cohen N, Koelle MR, Nitabach MN: Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans. Neuron. 2016 Dec 7; 2016 Nov 17. PMID: 27866800 Collins KM, Bode A, Fernandez RW, Tanis JE, Brewer JC, Creamer MS, Koelle MR: Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. Elife. 2016 Nov 16; 2016 Nov 16. PMID: 27849154 Koelle MR: Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans. WormBook. 2016 Mar 3; 2016 Mar 3. PMID: 26937633 Coleman BD, Marivin A, Parag-Sharma K, DiGiacomo V, Kim S, Pepper JS, Casler J, Nguyen LT, Koelle MR, Garcia-Marcos M: Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Mol Biol Evol. 2016 Mar; 2015 Dec 10. PMID: 26659249 Kosmaczewski SG, Han SM, Han B, Irving Meyer B, Baig HS, Athar W, Lin-Moore AT, Koelle MR, Hammarlund M: RNA ligation in neurons by RtcB inhibits axon regeneration. Proc Natl Acad Sci U S A. 2015 Jul 7; 2015 Jun 22. PMID: 26100902 Han B, Bellemer A, Koelle MR: An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Genetics. 2015 Apr; 2015 Feb 2. PMID: 25644702 Collins KM, Koelle MR: Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans. J Neurosci. 2013 Jan 9. PMID: 23303953