Ko, Albert Icksang - Yale University - Biological & Biomedical Sciences

个人简介

Professor Ko's research centers on the health problems that have emerged as a consequence of rapid urbanization and social inequity. He coordinates a research and training program on urban slum health in Brazil and is conducting prospective community-based studies on rat-borne leptospirosis, dengue, meningitis and respiratory infections. His research particularly focuses on understanding the transmission dynamics and natural history of leptospirosis, which is as a model for an infectious disease that has emerged in slum environments due to the interaction of climate, urban ecology and social marginalization. Current research combines multidisciplinary epidemiology, ecology and translational research-based approaches to identify prevention and control strategies that can be implemented in slum communities. More recently, Dr. Ko and his team has mobilized the public health research capacity at their site in the city of Salvador, Brazil to investigate the on-going outbreak of Zika virus infection and microcephaly. Dr. Ko is also Program Director at Yale for the Fogarty Global Health Equity Scholars Program which provides research training opportunities for US and LMIC post and pre-doctoral fellows at collaborating international sites. MD Harvard Medical School (1991) BS Massachusetts Institute of Technology (1981) Postdoctoral Fellow Weill Medical College of Cornell University Infectious Disease Fellow Massachusetts General Hospital Resident Brigham and Women's Hospital

研究领域

Dengue; Epidemiology; Leptospirosis; Urban Health; Global Health; Meningitis, Bacterial; Infectious Disease Medicine

近期论文

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Cathelicidin insufficiency in patients with fatal leptospirosis Lindow JC, Wunder Jr. EA, Popper SJ, Min JN, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery Jr N, Relman DA, Kim CC, Reis MG, Ko AI. Cathelicidin insufficiency in patients with fatal leptospirosis. PLoS Pathog 2016;12(11): e1005943. doi:10.1371/journal.ppat.1005943. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, Santos LA, Nery N Jr, Vasilakis N, Ko AI, de Almeida AR. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016;10(2):e0004517. doi: 10.1371/journal.pntd.0004517. PMID: 26914330; PMCID: PMC4767410. Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines Costa F, Sarno M, Khouri R, de Paulo Freitas B, Siqueira I, Ribeiro GS, Ribeiro HC, Campos GS, Alcântara LC, Reis MG, Weaver SC, Vasilakis N, Ko AI, Almeida AR. Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Ann Intern Med. 2016 Feb 24. doi: 10.7326/M16-0332. PMID: 26914810. Ocular Findings in Infants with Microcephaly Associated with Presumed Zika Virus Congenital Infection in Salvador, Brazil Freitas BP, Dias JRO, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort Jr R. Ocular Findings in Infants with Microcephaly Associated with Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016 Feb 9. doi: 10.1001/jamaophthalmol.2016.0267. PMID:26865554 Spatiotemporal determinants of urban leptospirosis transmission: Four-year prospective cohort study of slum residents in Brazil Hagan JE, Moraga P, Costa F, Capian N, Ribeiro GS, Wunder Jr EA, Felzemburgh RDM, Reis RB, Nery N, Santana FS, Fraga D, dos Santos BL, Santos AC, Queiroz A, Tassinari W, Carvalho MS, Reis MG, Diggle PJ, Ko AI. Spatiotemporal determinants of urban leptospirosis transmission: Four-year prospective cohort study of slum residents in Brazil. PLoS Negl Trop Dis. 2016 Jan 15;10(1):e0004275. doi: 10.1371/journal.pntd.0004275. PMID:26771379. PMCID: PMC4714915 Global Morbidity and Mortality of Leptospirosis: A Systematic Review. Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015 September; 9(9): e0003898. PMCID: PMC4574773 Urban epidemic of severe Leptospirosis in Brazil Ko AI, Reis MG, Dourado CR, Johnson Jr WD, Riley LW. Urban epidemic of severe Leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 1999;354:820-825. PMID: 10485724. do Rosário MS, de Jesus PA, Vasilakis N, Farias DS, Novaes MA, Rodrigues SG, Martins LC, Vasconcelos PF, Ko AI, Alcântara LC, de Siqueira IC: Guillain-Barré Syndrome After Zika Virus Infection in Brazil. Am J Trop Med Hyg. 2016 Nov 2; 2016 Sep 19. PMID: 27645785 Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, Dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J: Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infect Dis. 2016 Oct 3; 2016 Oct 3. PMID: 27716170 de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort R Jr: Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016 Feb 9; 2016 Feb 9. PMID: 26865554 Thomé S, Lessa-Aquino C, Ko AI, Lilenbaum W, Medeiros MA: Identification of immunodominant antigens in canine leptospirosis by Multi-Antigen Print ImmunoAssay (MAPIA). BMC Vet Res. 2014 Dec 3; 2014 Dec 3. PMID: 25466383 Hagan JE, Dias JS, Villasboas-Bisneto JC, Falcão MB, Ko AI, Ribeiro GS: Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report. Rev Soc Bras Med Trop. 2014 Mar-Apr. PMID: 24861306