Kleinstein, Steven H - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Steven Kleinstein received a B.A.S. in Computer Science from the University of Pennsylvania and a Ph.D. in Computer Science from Princeton University. He is currently an Associate Professor of Pathology and Immunobiology at the Yale School of Medicine, and a member of the Interdepartmental Program in Computational Biology and Bioinformatics, and the Human Translational Immunology Program. While formally trained in Computer Science, Dr. Kleinstein has been working on applications in immunology for nearly 20 years. His research combines techniques from dynamic modeling, systems biology and bioinformatics to capitalize on recent advances in immune profiling methods to characterize diverse states of the human immune system (in health and disease, and following infection and vaccination). PhD Princeton University (2002) BAS The University of Pennsylvania, Computer Science (1994)

研究领域

Autoimmune Diseases; Computing Methodologies; Immune System Diseases; Information Science; Pattern Recognition, Automated; Virus Diseases; Computational Biology; Autoimmune Diseases of the Nervous System; Immune System Phenomena; Mathematical Concepts; Patient-Specific Modeling

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Automated analysis of high-throughput B cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles Gadala-Maria D, Yaari G, Uduman M, Kleinstein SH. Automated analysis of high-throughput B cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles. Proceedings of the National Academies of Sciences. 2015. Feb 24;112(8):E862-70. doi: 10.1073/pnas.1417683112. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes Stern JNH*, Yaari G*, Vander Heiden JA*, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH**, Hafler DA** and O’Connor KC**. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine. 2014. Aug 6;6(248):248ra107. doi:10.1126/scitranslmed.3008879. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires Vander Heiden JA*, Yaari G*, Uduman M, Stern JNH, O’Connor KC, Hafler DA, Vigneault F and Kleinstein SH. Bioinformatics. 2014. Jul 1;30(13):1930-2. d Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data Gupta NT*, Vander Heiden JA*, Uduman M, Daniel Gadala-Maria, Yaari G and Kleinstein SH. Bioinformatics. 2015. Jun 10. pii: btv359. Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression Bolen CR*, Ding S*, Robek MD**, Kleinstein SH**. Hepatology. 2013. Aug 8. doi:10.1002/hep.26657. PMID: 23929627. Quantitative Set Analysis for Gene Expression: A method to quantify gene set differential expression including gene-gene correlations Yaari G*, Bolen CR*, Thakar J and Kleinstein SH. Nucleic Acids Research. 2013. doi: 10.1093/nar/gkt660. PMID: 23921631. Quantifying selection in high-throughput Immunoglobulin sequencing datasets Yaari G, Uduman M and Kleinstein SH. Nucleic Acids Research. 2012. doi:10.1093/nar/gks457 Watson CT, Matsen FA 4th, Jackson KJL, Bashir A, Smith ML, Glanville J, Breden F, Kleinstein SH, Collins AM, Busse CE: Comment on "A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data". J Immunol. 2017 May 1. PMID: 28416712 Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM: Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency. Immunity. 2017 Apr 18; 2017 Apr 11. PMID: 28410989 Gupta NT, Adams KD, Briggs AW, Timberlake SC, Vigneault F, Kleinstein SH: Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data. J Immunol. 2017 Mar 15; 2017 Feb 8. PMID: 28179494 Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC: Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing. J Immunol. 2017 Feb 15; 2017 Jan 13. PMID: 28087666 Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC: Solving Immunology? Trends Immunol. 2017 Feb; 2016 Dec 13. PMID: 27986392 Hudnall SD, Meng H, Lozovatsky L, Li P, Strout M, Kleinstein SH: Recurrent genetic defects in classical Hodgkin lymphoma cell lines. Leuk Lymphoma. 2016 Dec; 2016 Apr 27. PMID: 27121023 Maman Y, Teng G, Seth R, Kleinstein SH, Schatz DG: RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2. Nucleic Acids Res. 2016 Nov 16; 2016 Jul 19. PMID: 27436288 Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH: A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. J Immunol. 2016 Nov 1; 2016 Oct 5. PMID: 27707999 Toby IT, Levin MK, Salinas EA, Christley S, Bhattacharya S, Breden F, Buntzman A, Corrie B, Fonner J, Gupta NT, Hershberg U, Marthandan N, Rosenfeld A, Rounds W, Rubelt F, Scarborough W, Scott JK, Uduman M, Vander Heiden JA, Scheuermann RH, Monson N, Kleinstein SH, Cowell LG: VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements. BMC Bioinformatics. 2016 Oct 6; 2016 Oct 6. PMID: 27766961 Donius LR, Cheng Y, Choi J, Sun ZY, Hanson M, Zhang M, Gierahn TM, Marquez S, Uduman M, Kleinstein SH, Irvine D, Love JC, Reinherz EL, Kim M: Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J Virol. 2016 Oct 1; 2016 Sep 12. PMID: 27466419 Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J: Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection. Nat Commun. 2016 Aug 16; 2016 Aug 16. PMID: 27527920