Kazmierczak, Barbara Irene - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Kazmierczak received her Ph.D. from Rockefeller University (1993) and her M.D. from Cornell University Medical College (1994), both in New York City. She completed an Internal Medicine residency and Infectious Diseases fellowship training at the University of California, San Francisco. She began research on the opportunistic bacterial pathogen, Pseudomonas aeruginosa, while a postdoctoral scientist at UCSF. Dr. Kazmierczak joined the faculty at Yale School of Medicine in 2001. She currently holds appointments in both Internal Medicine (Infectious Diseases) and Microbial Pathogenesis. She sees hospitalized patients as an attending physician on the Infectious Diseases consult service. Her laboratory studies the bacterial and host factors that enable environmental bacteria, such as Pseudomonas aeruginosa and Staphylococcus aureus, to cause opportunistic infections. MD Cornell University Medical College (1994) PhD Rockefeller University (1993) BA University of Chicago (1986) MS University of Chicago (1986) Assistant Adjunct Professor University of California, San Francisco Fellow University of California, San Francisco Resident University of California, San Francisco Intern University of California, San Francisco Board Certification AB of Internal Medicine, Infectious Disease (1999, recertified: 2009)

研究领域

Bacterial Infections; Education, Medical, Graduate; Immunity, Innate; Microbiology; Pseudomonas; Biomedical Research; Host-Pathogen Interactions; Infectious Disease Medicine

近期论文

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Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Romberg N*, Al Moussawi K*, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI#, Lifton RP#. (2014) Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat Genet doi:10.1038/ng.3066 Cheating by Type 3 secretion system negative Pseudomonas aeruginosa during pulmonary infection. Czechowska K, McKeithen-Mead S, Al Moussawi K, Kazmierczak BI. (2014) Cheating by Type 3 secretion system negative Pseudomonas aeruginosa during pulmonary infection. PNAS 111: 7801-7806 Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Al Moussawi K, Kazmierczak BI. (2014) Distinct contributions of Interleukin (IL)-1a and IL-1ß to innate immune recognition of Pseudomonas aeruginosa in the lung. Infect Immun 82:4204-4211. Spatial and numerical regulation of flagellar biosynthesis in polarly-flagellated bacteria. Kazmierczak BI, Hendrixson DR. (2013) Spatial and numerical regulation of flagellar biosynthesis in polarly-flagellated bacteria. Mol Microbiol 88:655-63. The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. Schniederberend M, Abdurachim K, Murray TS, Kazmierczak BI (2013) The GTPase activity of FlhF is dispensable for flagellar localization, but not motility, in Pseudomonas aeruginosa. J Bacteriol 195: 1051-1060 Type IV pilus assembly in Pseudomonas aeruginosa over a broad range of c-di-GMP concentrations. Jain R, Behrens AJ, Kaever V, Kazmierczak BI. (2012) Type IV pilus assembly in Pseudomonas aeruginosa over a broad range of c-di-GMP concentrations. J Bacteriol 194:4285-4294. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an interluekin-1 dependent pathway. Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. (2011) Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an interluekin-1 dependent pathway. J Immunol 186: 7080-7088 Lin CK, Kazmierczak BI: Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. J Innate Immun. 2017; 2017 Feb 22. PMID: 28222444 Rundell EA, McKeithen-Mead SA, Kazmierczak BI: Rampant Cheating by Pathogens? PLoS Pathog. 2016 Sep; 2016 Sep 8. PMID: 27606630 Marion CR, Wang J, Sharma L, Losier A, Lui W, Andrews N, Elias JA, Kazmierczak BI, Roy CR, Dela Cruz CS: Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia. Infect Immun. 2016 Jul; 2016 Jun 23. PMID: 27141083 Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE: NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med. 2016 May 2; 2016 Apr 4. PMID: 27045008 Kazmierczak BI, Schniederberend M, Jain R: Cross-regulation of Pseudomonas motility systems: the intimate relationship between flagella, pili and virulence. Curr Opin Microbiol. 2015 Dec; 2015 Oct 23. PMID: 26476804 Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM: Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection. PLoS Pathog. 2015 Jan; 2015 Jan 26. PMID: 25621893 Al Moussawi K, Kazmierczak BI: Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Infect Immun. 2014 Oct; 2014 Jul 28. PMID: 25069982 Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP: Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat Genet. 2014 Oct; 2014 Sep 14. PMID: 25217960 Czechowska K, McKeithen-Mead S, Al Moussawi K, Kazmierczak BI: Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proc Natl Acad Sci U S A. 2014 May 27; 2014 May 12. PMID: 24821799 Jain R, Kazmierczak BI: A conservative amino acid mutation in the master regulator FleQ renders Pseudomonas aeruginosa aflagellate. PLoS One. 2014; 2014 May 14. PMID: 24827992 Kazmierczak BI, Hendrixson DR: Spatial and numerical regulation of flagellar biosynthesis in polarly flagellated bacteria. Mol Microbiol. 2013 May; 2013 Apr 21. PMID: 23600726