Kavathas, Paula B - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Kavathas graduated with a B.A. in American Institutions, from the University of Wisconsin, writing her thesis on the role of Science in America in the 1960s. She obtained her Ph.D. in Genetics from the Department of Genetics, founded in 1921 as the first Genetics Department in the country. At Wisconsin with Dr. Robert DeMars on genetic analysis of the MHC region. As a postdoctoral fellowship at Stanford University with Dr. Leonard Herzenberg she developed a novel approach for cloning genes for cell surface proteins using the fluorescence activated cell sorter (FACS). At Yale she continued her studies on CD8 and recently has focused on the functional relevance of four isoforms of the CD8b protein that exist in humans and great apes but not mice. They are differentially expressed in naive T cells, activated T cells, and memory T cells. Signal transduction by the isoforms is different given that they differ only in their cytoplasmic tail. The clinical relevance of these isoforms for adoptive immunotherapy with T cells is one focus of the lab. PhD University of Wisconsin-Madison (1980) BA University of Wisconsin-Madison (1972)

研究领域

Chlamydia trachomatis; Immune System; Immunotherapy; Molecular Biology; Medical Laboratory Science; Host-Pathogen Interactions

近期论文

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The human CD8ß M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. The human CD8ß M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. Thakral D, Coman MM, Bandyopadhyay A, Martin S, Riley JL, Kavathas PB. PLoS One. 2013;8(3):e59374. PMID: 23533620 Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis. Nod1, but not the ASC inflammasome, contributes to induction of IL-1ß secretion in human trophoblasts after sensing of Chlamydia trachomatis. Kavathas PB, Boeras CM, Mulla MJ, Abrahams VM. Mucosal Immunol. 2013 Mar;6(2):235-43. PMID: 22763410 Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S, Norwitz ER, Guller S, Abrahams VM. Am J Reprod Immunol. 2011 Jun;65(6):542-8. doi: 10.1111/j.1600-0897.2010.00960.x. The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. Merk M, Baugh J, Zierow S, Leng L, Pal U, Lee SJ, Ebert AD, Mizue Y, Trent JO, Mitchell R, Nickel W, Kavathas PB, Bernhagen J, Bucala R. J Immunol. 2009 Jun 1;182(11):6896-906. PMID: 19454686 Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production. Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production. de la Torre E, Mulla MJ, Yu AG, Lee SJ, Kavathas PB, Abrahams VM. J Immunol. 2009 Mar 15;182(6):3735-45. PMID: 19265152 Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. Liu W, Mani S, Davis NR, Sarrafzadegan N, Kavathas PB, Mani A. Circ Res. 2008 Nov 21;103(11):1280-8. PMID: 18948618 Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. J Immunol. 2008 Jun 1;180(11):7431-42. PMID: 18490743 Differential expression of the human CD8 beta splice-variants and regulation of the M-2 isoform by ubiquitination. Thakral, D., Dobbins, J., Devine, L. and Kavathas PB. (2008). Differential expression of the human CD8 beta splice-variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 11:7431-42. Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding. Devine, L., Thakral, D., Nag, S., Dobbins, J., Hodsdon, M., Kavathas, P.B. (2006) Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding. J. Immunol. 177:3930-3938. Severe tryptophan starvation blocks onset of conventional persistence and reduces reactivation of Chlamydia trachomatis. Lee SJ, Kavathas PB, Cresswell P (2007) Severe Tryptophan Starvation Blocks Onset of Conventional Persistence and Reduces Reactivation of Chlamydia trachomatis, Infect Immun, 75(11)5105-17