Katz, Samuel G - Yale University - Biological & Biomedical Sciences

个人简介

Samuel G. Katz graduated with a combined B.S./M.S. from Yale University in 1995. He then pursued dual M.D., Ph.D. training in the Health Sciences & Technology (HST) program jointly administered by MIT and Harvard. His Ph.D. thesis with Stuart H. Orkin focused on the transcriptional regulation of hematopoiesis. Sam then completed a residency in pathology and fellowship in hematopathology at Brigham and Women’s Hospital. He performed his post-doctoral studies on apoptosis with Loren D. Walensky at the Dana Farber Cancer Institute. As an Assistant Professor of Pathology at Yale University, Dr. Katz manages a laboratory deciphering the basic mechanisms of cell death and contributes to patient care as an active hematopathologist. MD Harvard Medical School (2004) PhD Harvard Medical School (2004) Fellowship Brigham & Women's Hospital Residency Brigham & Women's Hospital Board Certification AB of Pathology, Anatomic Pathology (2009) Board Certification AB of Pathology, Hematology (Pathology) (2009)

研究领域

Leukemia; Lymphoma; Stem Cells; Cell Death; Apoptosis; Genes, bcl-2; Endoplasmic Reticulum Stress

近期论文

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Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Oncogene 2013, 32(35):4078-85. A Stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. A Stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.. LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. J Clin Invest. 2012 Jun;122(6):2018-31. doi: 10.1172/JCI46231. Epub 2012 May 24. BAX activation is initiated at a novel interaction site. Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu H-C, Kim H, Cheng EH-Y., Tjandra N, Walensky LD. Nature 2008; 455:1076-1081. Endothelial lineage mediated loss of the GATA cofactor FOG-1 impairs cardiac development. Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. PNAS 2003; 100:14030-14035. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Katz SG*, Cantor AB*, Orkin SH. Mol Cell Biol 2002; 22:3121-3128. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Katz SG, Labelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Blood. 2014 Feb 6;123(6):884-93. Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. ACS Chem Biol. 2014 Mar 21;9(3):831-7. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7201-6. Katz SG: EZH! The IRE of DLBCL gets an UPR hand. Blood. 2017 Apr 27. PMID: 28450573 Gross A, Katz SG: Non-apoptotic functions of BCL-2 family proteins. Cell Death Differ. 2017 Feb 24; 2017 Feb 24. PMID: 28234359 Xu ML, Acevedo-Gadea C, Seropian S, Katz SG: Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology. 2016 Jul; 2016 Jan 26. PMID: 26648051 Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG: Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation. Proc Natl Acad Sci U S A. 2016 Feb 2; 2016 Jan 25. PMID: 26811485 Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG: BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2015 Jun 9; 2015 May 26. PMID: 26015568