Kaech, Susan - Yale University - Biological & Biomedical Sciences

个人简介

Stanford University Ph.D., Developmental Biology 1993-1998 University of Washington, Seattle, WA B.S., Cellular and Molecular Biology 1989-1993 1990-1991 Undergraduate Researcher, Div. of Basic Sciences, Fred Hutchinson Cancer Research Center 1991-1993 Undergraduate Researcher, Dept. of Zoology, University of Washington, Seattle 1993-1998 Graduate Student, Dept. of Developmental Biology, Stanford University 1999-2004 Postdoctoral Fellow, Dept. of Microbiology and Immunology and Emory Vaccine Center, Emory University 2004-2009 Assistant Professor, Department of Immunobiology, Yale University 2009-2015 Associate Professor, Department of Immunobiology, Yale University 2015-present Professor, Department of Immunobiology, Yale University 2009-2015 HHMI Early Career Scientist

研究领域

T-Lymphocytes; Vaccines; Global Health; Developmental Biology; Infectious Disease Medicine

近期论文

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FoxO1 directly regulates the expression of PD-1 and sustains viral specific CD8+ T-cell responses during chronic infection. Staron M, Gray S, Li MO, Ip WK, Kaech SM. FoxO1 directly regulates the expression of PD-1 and sustains viral specific CD8+ T-cell responses during chronic infection. Immunity 41(5) 802-14 (2014). PMCID in Progress CD4 T cells required for development and function of tissue resident memory CD8 T cells through a T-bet-dependent mechanism. Laidlaw BJ, Zhang N, Craft J, Kaech SM. CD4 T cells required for development and function of tissue resident memory CD8 T cells through a T-bet-dependent mechanism. Immunity 41(4):633-45 (2014). PMCID in Progress. Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ. Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM. Immune-based antitumor effects of BRAF Inhibitors rely on signaling by CD40L and IFN-?. Cancer Res, 74(12):3205-17 (2014). PMCID: PMC4063281. TLR4 ligands LPS and MPLA differentially regulate effector and memory CD8+ T cell differentiation. Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH and Kaech SM. TLR4 ligands LPS and MPLA differentially regulate effector and memory CD8+ T cell differentiation. J Immunol, 92(9):4221-32 (2014). PMCID: PMC4071140. Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells. Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells. Immunity 40(3):367-77 (2014). PMCID: PMC3992517. Parish, IA, Marshall HD, Staron M, Lang PA, Brüstle A, Chen JH, Cui W, Ohashi PS, Weaver CT and Kaech SM. Blimp-1 triggers the formation of immunoregulatory IL-10 producing Th1 cells during chronic viral infection. J Clin Invest, 124(8):3455-68 (2014). PMCID: PMC4109559. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 19:4957-64 (2012). PMID:224840449. PMCID in Progress. An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Cui W, Liu Y, Weinstein JS, Craft J & Kaech SM. An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35:792-805 (2011). PMCID in progress. Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rustishauser R, Cui W, Kleinstein SH, Craft J and Kaech SM. Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection. Immunity 35:633-46 (2011). PMCID in process. Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW and Kaech SM. Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol 187(8):4068-76 (2011). PMCID in process. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. Jung YW, Rutishauser R, Nikhil JS, Haberman AM and Kaech SM. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol 185:5315-25 (2010). PMCID in progress. Differential effects of STAT5 and P13K/AKT signaling on effector and memory CD8 T cell survival. Hand TW, Jung YW, Cui W, Sefik E, Liu Y, Joshi NS, Chandele A and Kaech SM. Differential effects of STAT5 and P13K/AKT signaling on effector and memory CD8 T cell survival. PNAS 107:16601-6 (2010). PMCID: PMC2944719. In vivo regulation of Bcl6 and T follicular helper cell development.