Kaczmarek, Leonard Konrad - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of London (1971)

研究领域

Ion Channels; Learning; Memory; Neurosciences; Pharmacology; Physiology

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

De novo gain of function KCNT1 channel mutations cause developmental arrest and seizures in malignant migrating partial seizures of infancy Barcia, G., Fleming, M.R, Deligniere, A., Gazula. V.-R., Brown, M.R., Longouet, M., Chen, H., Kronengold, J., Abhyankar, A., Kaminska, A., Boddaert, N., Casanova, J.-L., Desguerre, I., Munnich, A., Dulac, O., Kaczmarek, L.K., Colleaux, L and Nabbout, R. De novo gain of function KCNT1 channel mutations cause developmental arrest and seizures in malignant migrating partial seizures of infancy, Nature Genetics, 44: 1255-1259, 2012. PMCID: PMC 3687547 The fragile X mental retardation protein controls gating of the sodium-activated potassium channel Brown, M.R., Kronengold, J., Gazula, V.-R., Chen, Y., Strumbos, J.G., Sigworth, F.J., Navaratnam, D. and Kaczmarek, L.K. The fragile X mental retardation protein controls gating of the sodium-activated potassium channel, Slack, Nature Neuroscience, 13: 819–821, 2010. PMCID: PMC 2893252 Non-conducting functions of ion channels. Kaczmarek LK. Non-conducting functions of ion channels. Nature Rev Neurosci, 7:761-771, 2006. Acoustic stimulation rapidly alters intrinsic excitability of auditory neurons. Song P, Yang Y, Barnes-Davies M, Bhattacharjee A, Hamann M, Forsythe ID, Oliver DL, Kaczmarek LK. Acoustic stimulation rapidly alters intrinsic excitability of auditory neurons. Nature Neurosci, 8:1335-1342, 2005. Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors. Fleming MR, Kaczmarek LK. Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors. J Recept Signal Transduct Res, 29(3-4):173-81, 2009. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. J Neurosci, 29(17):5654-65, 2009. Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, El Manira A. Na⁺-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proc Natl Acad Sci USA, 105(52):20941-6, Epub 2008 Dec 18. Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF: A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. PLoS One. 2017; 2017 May 3. PMID: 28467418 Zhang Y, Ni W, Horwich AL, Kaczmarek LK: An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons. J Neurosci. 2017 Feb 22; 2017 Jan 24. PMID: 28119399 Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H: International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 Jan; 2016 Nov 15. PMID: 28267675 Onorati M, Li Z, Liu F, Sousa AM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N: Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284 Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK: Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545877 Zhang Y, Kaczmarek LK: Kv3.3 potassium channels and spinocerebellar ataxia. J Physiol. 2016 Aug 15; 2015 Nov 15. PMID: 26442672 Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK: Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. J Neurophysiol. 2016 Jul 1; 2016 Apr 6. PMID: 27052580 Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK: Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7; 2016 Mar 17. PMID: 26997484 Gribkoff VK, Kaczmarek LK: The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology. 2016 Mar 12; 2016 Mar 12. PMID: 26979921 Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA: T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. PLoS One. 2016; 2016 Jan 27. PMID: 26815481 Bausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R: The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice. Learn Mem. 2015 Jul; 2015 Jun 15. PMID: 26077685