Iwasaki, Akiko - Yale University - Biological & Biomedical Sciences

个人简介

Akiko Iwasaki received her Ph.D. from the University of Toronto (Canada) in 1998, and her postdoctoral training from the National Institutes of Health (USA) (1998-2000). She joined Yale University (USA) as a faculty in 2000, and currently is an Investigator of the HHMI and a Professor of Department of Immunobiology and Department of Molecular Cellular and Developmental Biology. Akiko Iwasaki’s research focuses on the mechanisms of immune defense against viruses at the mucosal surfaces. Her laboratory is interested in how innate recognition of viral infections lead to the generation of adaptive immunity, and how adaptive immunity mediates protection against subsequent viral challenge. PhD University of Toronto (1998)

研究领域

Autophagy; Herpes Simplex; Immune System; Immunity, Cellular; Immunity, Innate; Influenza, Human; Molecular Biology; Sexually Transmitted Diseases; Inflammasomes

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Iijima N and Iwasaki A: T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science. 2014 Oct 3;346 (6205) :93-8. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Shin H and Iwasaki A: A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature. 2012 Nov 15;491 (7424) :463-7. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM and Iwasaki A. PNAS, January 5, 2015 DOI: 10.1073/pnas.1411030112 Control of adaptive immunity by the innate immune system. Iwasaki A and Medzhitov R: Control of adaptive immunity by the innate immune system. Nat Immunol. 2015 Apr;16 (4) :343-53. CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE and Iwasaki A: CD301b? dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity. 2013 Oct 17;39 (4) :733-43. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus. Pang IK, Ichinohe T and Iwasaki A: IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus. Nat Immunol. 2013 Mar;14 (3) :246-53. Innate Immune Recognition of HIV-1. Immunity. Iwasaki A. Innate Immune Recognition of HIV-1. Immunity. 2012 Sep 21;37(3):389-98. A virologic view of innate viral recognition. Iwasaki A. A virologic view of innate viral recognition. Annual review of microbiology 2012 Oct 13;66:177-96. A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus. Yordy B, Iijima N, Huttner A, Leib D, Iwasaki A. A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus. Cell Host Microbe. 2012 Sep 13;12(3):334-45. Genome-virome interactions: examining the role of common viral infections in complex disease. Foxman, EF, and Iwasaki, A. Genome-virome interactions: examining the role of common viral infections in complex disease. Nat Rev Microbiol 2011 Apr;9(4):254-64. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Sasai M, Linehan MM, Iwasaki A. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science 2010 Sep 17;329(5998):1530-4. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A. Immunity. 2010 Feb 26;32(2):227-239. CTL mobilization to virus-infected tissue requires CD4+ T cell help.