Howard, Jonathon - Yale University - Biological & Biomedical Sciences

个人简介

Jonathon (Joe) Howard is the Eugene Higgins Professor of Molecular Biophysics & Biochemistry and a Professor of Physics at Yale University. He is best known for his research on motor proteins and the cytoskeleton, and the development of techniques for observing and manipulating individual biological molecules. Brought up in Australia, where he studied at the Australian National University, he has had a distinguished career in the United States—he was a professor at the University of Washington Medical School in Seattle—and in Germany, where he played a key role, as Director, in establishing the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, one of the most successful research institutes in Europe. In 2013 he returned to the United States where he enjoys teaching, writing and new research projects on cell motility and neuronal morphology. PhD Australian National Univ (1983) BS Australian National Univ (1979)

研究领域

Biophysics; Microtubules; Mitosis; Molecular Biology; Physics; Molecular Motor Proteins; Nanotechnology; Axoneme; Biostatistics

近期论文

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A force-generating machinery maintains the spindle at the cell center during mitosis. Garzon-Coral C, Fantana H & Howard J (2016) A force-generating machinery maintains the spindle at the cell center during mitosis. Science 352, 1124–1127. Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella. Sartori P, Geyer VF, Jülicher F & Howard J (2016) Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella. eLife 5, 343-368. Independent control of static and dynamic components of the Chlamydomonas flagellar beat. Geyer VF, Sartori P, Jülicher F & Howard J (2016) Independent control of static and dynamic components of the Chlamydomonas flagellar beat. Current Biology 26, 1098–1103. Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. Hibbel A, Bogdanova A, Mahamdeh M, Jannasch A, Storch M, Schäffer E, Liakopoulos D & Howard J (2015). Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. eLife 4 e10542. doi: 10.7554/eLife Quantitative cell biology: the essential role of theory. Howard J (2014) Quantitative cell biology: the essential role of theory. Mol Biol Cell. 25:3438-3440. A NOMPC-dependent membrane-microtubule connector is a candidate for the gating spring in fly mechanoreceptors. Liang X, Madrid J, Gärtner R, Verbavatz JM, Schiklenk C, Wilsch-Bräuninger M, Bogdanova A, Stenger F, Voigt A, Howard J. (2013) A NOMPC-dependent membrane-microtubule connector is a candidate for the gating spring in fly mechanoreceptors. Curr Biol. 23:755-63. Molecular crowding creates traffic jams of kinesin motors on microtubules. Leduc, C., Padberg-Gehle, K., Varga, V., Helbing, D., Diez, S. & Howard, J. (2012) Molecular crowding creates traffic jams of kinesin motors on microtubules. Proc. Natl. Acad. Sci. U S A. 109: 6100-6105. Coombes C, Yamamoto A, McClellan M, Reid TA, Plooster M, Luxton GW, Alper J, Howard J, Gardner MK: Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1. Proc Natl Acad Sci U S A. 2016 Nov 15; 2016 Nov 1. PMID: 27803321 Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J: The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability. Biophys J. 2016 Oct 18. PMID: 27760363 Sartori P, Geyer VF, Howard J, Jülicher F: Curvature regulation of the ciliary beat through axonemal twist. Phys Rev E. 2016 Oct; 2016 Oct 28. PMID: 27841522 Xiao X, Geyer VF, Bowne-Anderson H, Howard J, Sbalzarini IF: Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets. Med Image Anal. 2016 Aug; 2016 Apr 4. PMID: 27104582 Garzon-Coral C, Fantana HA, Howard J: A force-generating machinery maintains the spindle at the cell center during mitosis. Science. 2016 May 27. PMID: 27230381 Sartori P, Geyer VF, Scholich A, Jülicher F, Howard J: Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella. Elife. 2016 May 11; 2016 May 11. PMID: 27166516 Battle C, Broedersz CP, Fakhri N, Geyer VF, Howard J, Schmidt CF, MacKintosh FC: Broken detailed balance at mesoscopic scales in active biological systems. Science. 2016 Apr 29. PMID: 27126047 Geyer VF, Sartori P, Friedrich BM, Jülicher F, Howard J: Independent Control of the Static and Dynamic Components of the Chlamydomonas Flagellar Beat. Curr Biol. 2016 Apr 25; 2016 Mar 31. PMID: 27040779 Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E: Microtubules: 50 years on from the discovery of tubulin. Nat Rev Mol Cell Biol. 2016 Apr 22. PMID: 27103327 Carrillo Oesterreich F, Herzel L, Straube K, Hujer K, Howard J, Neugebauer KM: Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II. Cell. 2016 Apr 7; 2016 Mar 24. PMID: 27020755 Hibbel A, Bogdanova A, Mahamdeh M, Jannasch A, Storch M, Schäffer E, Liakopoulos D, Howard J: Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. Elife. 2015 Nov 18; 2015 Nov 18. PMID: 26576948