Horvath, Tamas L - Yale University - Biological & Biomedical Sciences

个人简介

Tamas Horvath is Professor and Chair of the Department of Comparative Medicine and Professor of Neurobiology and Ob/Gyn at Yale University School of Medicine, New Haven, Connecticut. He is also the Director for the Yale Program on Integrative Cell Signaling and Neurobiology of Metabolism. He received a Doctor of Veterinary Medicine (D.V.M.) degree from the Faculty of Veterinary Sciences in Budapest, Hungary, and a Doctor of Philosophy (Ph.D.) degree from the University of Szeged in Hungary. His research has been focusing on neuronal circuitries that support physiological and pathological homeostatic conditions, including processes associated with reproduction, energy metabolism and neurodegeneration. PhD Szeged University (2000) DVM University of Veterinary Sciences, Budapest (1992)

研究领域

Neuroendocrinology; Obesity; Physiology

近期论文

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Hypothalamic Agrp Neurons drive Stereotypic Behaviors Beyond Feeding. Dietrich MO, Zimmer MR, Bober J, Horvath TL (2015) Hypothalamic Agrp Neurons drive Stereotypic Behaviors Beyond Feeding. Cell 160:1222-1232. Published online March 4 2015. DOI: http://dx.doi.org/10.1016/j.cell.2015.02.02 Hypothalamic POMC neurons promote cannabinoid-induced feeding. Koch M, Varela L, Kim JG, Kim JD, Hernandez F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao X-B, Diano S, Horvath TL (2015) Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 519(7541):45-50. doi: 10.1038/nature14260. Epub 2015 Feb 18. Leptin signaling in atsrocytes regulates hypothalamic neuronal circuits and feeding. Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL (2014) Leptin signaling in atsrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience 17(7):908-10. doi: 10.1038/nn.3725. Epub 2014 Jun 1. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high fat feeding. Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC (2014) Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high fat feeding. Cell. 156:495-509. Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Dietrich MO, Liu Z-W, Horvath TL (2013) Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell 155(1):188-99. doi: 10.1016/j.cell.2013.09.004. Ralevski E, Horvath TL, Shanabrough M, Hayden R, Newcomb J, Petrakis I: Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. Alcohol Alcohol. 2017 May 8; 2017 May 8. PMID: 28481974 Mancini G, Horvath TL: Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link. Trends Cell Biol. 2017 May 6; 2017 May 6. PMID: 28487182 Chowen JA, Horvath TL, Argente J: Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean? Diabetes. 2017 Apr. PMID: 28325742 Varela L, Suyama S, Huang Y, Shanabrough M, Tschoep MH, Gao XB, Giordano FJ, Horvath TL: Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. Diabetes. 2017 Mar 14; 2017 Mar 14. PMID: 28292966 Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T: Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat Neurosci. 2017 Feb; 2016 Dec 19. PMID: 27991900 Morozov YM, Koch M, Rakic P, Horvath TL: Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus. Mol Metab. 2017 Apr; 2017 Jan 27. PMID: 28377876 Harkany T, Horvath TL: (S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity. Cell Metab. 2017 Jan 10. PMID: 28076767 Somogyi V, Horváth TL, Tóth I, Bartha T, Frenyó LV, Kiss DS, Jócsák G, Kerti A, Naftolin F, Zsarnovszky A: Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture. Acta Vet Hung. 2016 Dec. PMID: 27993100 Aldo P, You Y, Szigeti K, Horvath TL, Lindenbach B, Mor G: HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells. Am J Reprod Immunol. 2016 Nov; 2016 Sep 10. PMID: 27613665 Gao XB, Horvath TL: Feeding Behavior: Hypocretin/Orexin Neurons Act between Food Seeking and Eating. Curr Biol. 2016 Sep 26. PMID: 27676302 Onorati M, Li Z, Liu F, Sousa AM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N: Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284 Chowen JA, Argente-Arizón P, Freire-Regatillo A, Frago LM, Horvath TL, Argente J: The role of astrocytes in the hypothalamic response and adaptation to metabolic signals. Prog Neurobiol. 2016 Sep; 2016 Mar 18. PMID: 27000556 Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL, Iwasaki A: Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell. 2016 Aug 25. PMID: 27565347 García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH: Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016 Aug 11. PMID: 27518562 Kim KE, Jung Y, Min S, Nam M, Heo RW, Jeon BT, Song DH, Yi CO, Jeong EA, Kim H, Kim J, Jeong SY, Kwak W, Ryu do H, Horvath TL, Roh GS, Hwang GS: Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism. Sci Rep. 2016 Jul 21; 2016 Jul 21. PMID: 27439777