Horsley, Valerie - Yale University - Biological & Biomedical Sciences

个人简介

Valerie Horsley began her scientific training as an undergraduate at Furman University and was awarded her Ph.D. from Emory University. After completing a Damon Runyon Cancer Research Foundation postdoctoral fellowship in Elaine Fuchs’ laboratory at Rockefeller University, Valerie started her independent laboratory at Yale University in the Department of Molecular Cellular and Developmental Biology. Horsley’s lab uses the mouse as a genetic model system to study how adult stem cells within epithelial tissues maintain tissue homeostasis, can contribute to wound healing, and can be a factor in cancer formation. She is now the Maxine F. Singer Associate Professor of Molecular, Cellular, and Developmental Biology at Yale, has received a number of awards including the Pew Scholar Award, Presidential Early Career Award for Scientists and Engineers, and the Rosalind Franklin Young Investigator Award. PhD Emory University (2003) BS Furman University, Biology (1998) Postdoctoral Fellow Rockefeller University

研究领域

Dermatology; Epithelial Cells; Molecular Biology; Regeneration; Skin Diseases; Stem Cells; Tissue Survival

近期论文

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NFATc1 balances quiescence and proliferation of skin stem cells. V. Horsley, A. O. Aliprantis, L. Polak, L.H.Glimcher and E. Fuchs. (2008). NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 132(2):299-310. Blimp1 defines a novel progenitor population that governs cellular input to the sebaceous gland. V. Horsley, D. O’Carroll, R. Tooze, Y. Ohinata, M.Saitou, T. Obukhanych, M. Nussenzweig, A. Tarakhovsky and E. Fuchs. (2006). Blimp1 defines a novel progenitor population that governs cellular input to the sebaceous gland. Cell. 126(3):597-609. Adipocyte precursor cells contribute to the skin stem cell niche. E. Festa, J. Fretz, R. Berry, B. Schmidt, M. Rodeheffer, M. Horowitz and V. Horsley. (2011) Adipocyte precursor cells contribute to the skin stem cell niche. Cell. 146(5): 761-771. Intradermal adipocytes regulate fibroblast function during skin wound healing. B. Schmidt and V. Horsley. (2013) Intradermal adipocytes regulate fibroblast function during skin wound healing. Development. 140(7): 1517-27. Intercellular adhesions organize epithelial cell-matrix mechanics. A. F. Mertz, Y. Che, S. Banerjee, J. Goldstein, S. Revilla, C. Niessen, M. C. Marchetti, E. R. Dufresne and V. Horsley (2013). Intercellular adhesions organize epithelial cell-matrix mechanics. PNAS. 110(3):842-7. Transcriptional profiling of keratinocyte specification in human embryonic stem cells. A. Tadeu, S. Lin, L. Hou, L. Chung, M. Zhong, H. Zhoa and V. Horsley. (2015) Transcriptional profiling of keratinocyte specification in human embryonic stem cells. Plos One. 10: e0122493. Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential. K. Rosowski, A. Mertz, S. Norcross, E. Dufresne, and V. Horsley. (2015) Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential. Sci. Rep. 5: 14218. Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. R. Stewart, A. Zubek, K. Rosowski, S. Schreiner, V. Horsley*, and M. King* (*co-corresponding author). (2015) LINC complexes support hair follicle integrity and intercellular adhesion. J. Cell Biol. 209: 403-18. Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. J. Goldstein, E. Roth, N. Roberts, R. Zwick, S. Lin, S. Fletcher, A. Tadeu, C. Wu, A. Beck, C. Zeiss, M. Suarez-Farinas and V. Horsley. (2015) Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Mol. Biol. Cell. pii: mbc.E15-05-0282. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis G. C. Rivera-Gonzalez, B.A. Shook, B. Holtrup, K. Bollag, M. S. Rodeheffer and V. Horsley. (2016) Adipocyte stem cell self-renewal is regulated by a Pdgfa/Akt signalling axis in the skin. Cell Stem Cell. 2016 Oct 1. pii: S1934-5909(16)30296-X. In Press.