Holley, Scott Alan - Yale University - Biological & Biomedical Sciences

个人简介

My doctoral research at the University of Chicago with Chip Ferguson demonstrated the conservation of dorsal-ventral patterning mechanisms between insects and vertebrates, identified noggin as a BMP inhibitor and originated concept of facilitated morphogen diffusion. I was a Damon Runyon Cancer Research Foundation Postdoctoral Fellow with Nobel Laureate Christiane Nüsslein-Volhard at the Max Planck Institute for Developmental Biology in Tübingen, Germany. As a postdoc, I discovered the zebrafish segmentation clock, a genetic mechanism that leads to vertebral defects such as scoliosis when perturbed in humans. My lab at Yale studies systems developmental biology, biophysics and biomechanics of vertebral column development in zebrafish. We combine in vivo biophysics, embryology, genetics, live imaging and systems level data analysis and computer modeling to study pattern formation and morphogenesis. Our experimental approach is driven by the idea that quantitative in vivo analysis will lead to fundamental insights into the emergence of biological organization from the collective interaction of its constituent parts. My lab’s research has been supported by grants from the NIH, NSF, the American Cancer Society and the March of Dimes. PhD University of Chicago, Postdoctoral Fellow Max Planck Institut für Entwicklungsbiologie, Tübingen, Germany

研究领域

Biomechanical Phenomena; Genetics; Zebrafish; Developmental Biology; Organogenesis; Systems Biology

近期论文

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A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. McMillen, P., Chatti, V. Jülich, D. and Holley, S.A. 2016. A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Curr Biol, 26: 542-549. Cross-scale Integrin regulation self-organizes ECM and tissue topology. Jülich, D., Cobb, G., Melo, A.M., McMillen, P., Lawton, A.K., Mochie, S. G. J., Rhoades, E., and Holley, S.A. 2015. Cross-scale Integrin regulation self-organizes ECM and tissue topology. Dev Cell, 34:33-44. Cell-Fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Dray, N., Lawton, A.K., Nandi, A., Jülich, D., Emonet, T. and Holley, S.A. 2013. Cell-Fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Curr Biol, http://dx.doi.org/10.1016/j.cub.2013.05.052 Regulated tissue fluidity steers zebrafish body elongation. Lawton, A.K., Nandi, A., Stulberg, M.J., Dray, N., Sneddon, M.W., Pontius, W., Emonet, T. and Holley, S.A. 2013. Regulated tissue fluidity steers zebrafish body elongation. Development, 140: 573-582. PMCID: PMC3561786 The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Trofka, A., Schwendinger-Schreck, J., Brend, T., Pontius, W., Emonet, T., Holley, S.A. 2012. The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development 139: 940-7. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud Stulberg, M.J., Lin, A., Zhao H., Holley, S.A. 2012. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Dev Biol 369, 298-307. Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling Jülich, D., Mould, A.P., Koper, E., and Holley, S.A. 2009. Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling. Development 136: 2913-2921. McMillen P, Chatti V, Jülich D, Holley SA: A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Curr Biol. 2016 Feb 22; 2016 Feb 4. PMID: 26853361 McMillen P, Holley SA: Integration of cell-cell and cell-ECM adhesion in vertebrate morphogenesis. Curr Opin Cell Biol. 2015 Oct; 2015 Jul 17. PMID: 26189063 Yin ES, Rakhmankulova M, Kucera K, de Sena Filho JG, Portero CE, Narváez-Trujillo A, Holley SA, Strobel SA: Fusaric acid induces a notochord malformation in zebrafish via copper chelation. Biometals. 2015 Aug; 2015 Apr 26. PMID: 25913293 Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA: Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Dev Cell. 2015 Jul 6; 2015 Jun 18. PMID: 26096733 McMillen P, Holley SA: The tissue mechanics of vertebrate body elongation and segmentation. Curr Opin Genet Dev. 2015 Jun; 2015 Mar 19. PMID: 25796079 Schwendinger-Schreck J, Kang Y, Holley SA: Modeling the zebrafish segmentation clock's gene regulatory network constrained by expression data suggests evolutionary transitions between oscillating and nonoscillating transcription. Genetics. 2014 Jun; 2014 Mar 24. PMID: 24663100 Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley SA: Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Curr Biol. 2013 Jul 22; 2013 Jun 27. PMID: 23810535 Lackner S, Schwendinger-Schreck J, Jülich D, Holley SA: Segmental assembly of fibronectin matrix requires rap1b and integrin α5. Dev Dyn. 2013 Feb; 2013 Jan 7. PMID: 23192979 Lawton AK, Nandi A, Stulberg MJ, Dray N, Sneddon MW, Pontius W, Emonet T, Holley SA: Regulated tissue fluidity steers zebrafish body elongation. Development. 2013 Feb 1. PMID: 23293289 Stulberg MJ, Lin A, Zhao H, Holley SA: Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Dev Biol. 2012 Sep 15; 2012 Jul 14. PMID: 22796649 Trofka A, Schwendinger-Schreck J, Brend T, Pontius W, Emonet T, Holley SA: The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development. 2012 Mar; 2012 Jan 25. PMID: 22278920