Higley, Michael J - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Higley studied behavioral neuroscience at Cornell University. He then completed his MD and PhD in the MSTP Program and the laboratory of Dr. Diego Contreras at the University of Pennsylvania. He continued his scientific training as a postdoctoral fellow with Dr. Bernardo Sabatini at Harvard Medical School and joined the faculty of the Yale Department of Neuroscience in 2010. MD/PhD University of Pennsylvania (2007) BA Cornell University (1998) Postdoctoral Fellow, Sabatini Lab Harvard Medical School

研究领域

Autistic Disorder; Dendrites; Electrophysiology; Neurobiology; Schizophrenia; Neurodegenerative Diseases; Microscopy, Fluorescence, Multiphoton

近期论文

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Compartmentalization of GABAergic inhibition by dendritic spines. Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies G, and Higley MJ. Compartmentalization of GABAergic inhibition by dendritic spines. Science, 340:759-62. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Higley MJ and Sabatini BL. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nature Neuroscience 13:958-66, 2010. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Higley MJ*, Soler-Llavina G*, and Sabatini BL. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nature Neuroscience,12:1121-28, 2009. Calcium signaling in dendrites and spines: practical and functional considerations. Higley MJ and Sabatini BL. Calcium signaling in dendrites and spines: practical and functional considerations. Neuron 59: 902-13, 2008. Cellular mechanisms of suppressive interactions between somatosensory responses in vivo. Higley MJ and Contreras D. Cellular mechanisms of suppressive interactions between somatosensory responses in vivo. J. Neurophys. 97:647-58, 2007 Balanced excitation and inhibition determine spike timing during frequency adaptation. Higley MJ and Contreras D. Balanced excitation and inhibition determine spike timing during frequency adaptation. J Neurosci 26: 448-57, 2006. Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ: Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. J Neurosci. 2016 Jun 22. PMID: 27335408 Kannan M, Gross GG, Arnold DB, Higley MJ: Visual Deprivation During the Critical Period Enhances Layer 2/3 GABAergic Inhibition in Mouse V1. J Neurosci. 2016 Jun 1. PMID: 27251614 Lur G, Vinck MA, Tang L, Cardin JA, Higley MJ: Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks. Cell Rep. 2016 Mar 22; 2016 Mar 10. PMID: 26972011 Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF: Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Biol Psychiatry. 2015 Dec 15; 2015 Feb 4. PMID: 25731884 Lur G, Higley MJ: Glutamate Receptor Modulation Is Restricted to Synaptic Microdomains. Cell Rep. 2015 Jul 14; 2015 Jul 2. PMID: 26146087 Higley MJ, Picciotto MR: Neuromodulation by acetylcholine: examples from schizophrenia and depression. Curr Opin Neurobiol. 2014 Dec; 2014 Jun 28. PMID: 24983212 Higley MJ: Localized GABAergic inhibition of dendritic Ca(2+) signalling. Nat Rev Neurosci. 2014 Sep; 2014 Aug 13. PMID: 25116141 Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ: Compartmentalization of GABAergic inhibition by dendritic spines. Science. 2013 May 10. PMID: 23661763 Einstein EB, Asaka Y, Yeckel MF, Higley MJ, Picciotto MR: Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci. 2013 May; 2013 Feb 7. PMID: 23387435 Picciotto MR, Higley MJ, Mineur YS: Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron. 2012 Oct 4. PMID: 23040810 Higley MJ, Sabatini BL: Calcium signaling in dendritic spines. Cold Spring Harb Perspect Biol. 2012 Apr 1; 2012 Apr 1. PMID: 22338091 Higley MJ, Strittmatter SM: Neuroscience. Lynx for braking plasticity. Science. 2010 Nov 26. PMID: 21109660