Herold, Kevan - Yale University - Biological & Biomedical Sciences

个人简介

My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies I have also been very interested in analysis of beta cell function in Type 1 diabetes. MD Jefferson Medical College (1979) BS Pennsylvania State University (1977) Resident Temple University Hospital Fellow University of Chicago Board Certification AB of Internal Medicine, Internal Medicine (1982) Board Certification AB of Internal Medicine, Endocrinology & Metabolism (1985)

研究领域

Diabetes Mellitus, Type 1; Endocrine System Diseases; Immune System Diseases; Metabolism; Autoimmunity; Translational Medical Research

近期论文

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Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and IL-1 blockade: evidence of improved immune regulation Ablamunits V, Henegariu O, Hansen JB, Opare-Addo L, Preston-Hurlburt P, Santamaria P, Mandrup-Poulsen T, and Herold KC. Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and IL-1 blockade: evidence of improved immune regulation (in press) Diabetes. Detection of beta cell death in diabetes using differentially methylated circulating DNA Akirav E, Lebastchi J, Galvan EM, Henegariu O, Akirav M, Ablamunits V, Lizardi PM, and Herold KC. Detection of beta cell death in diabetes using differentially methylated circulating DNA (in press) Proc Nat'l Acad Sci (USA) Rui J, Deng S, Arazi A, Perdigoto AL, Liu Z, Herold KC: β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metab. 2017 Mar 7; 2017 Feb 9. PMID: 28190773 Mesquita PMM, Preston-Hurlburt P, Keller MJ, Vudattu N, Espinoza L, Altrich M, Anastos K, Herold KC, Herold BC: Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus-Herpes Simplex Virus Coinfection. J Infect Dis. 2017 Feb 15. PMID: 28007920 Beam CA, MacCallum C, Herold KC, Wherrett DK, Palmer J, Ludvigsson J, Type 1 Diabetes TrialNet Study Group.: GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis. Diabetologia. 2017 Jan; 2016 Oct 4. PMID: 27704166 Durning SP, Preston-Hurlburt P, Clark PR, Xu D, Herold KC, Type 1 Diabetes TrialNet Study Group.: The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. J Immunol. 2016 Oct 15; 2016 Sep 21. PMID: 27655844 Herrin M, Tate JP, Akgün KM, Butt AA, Crothers K, Freiberg MS, Gibert CL, Leaf DA, Rimland D, Rodriguez-Barradas MC, Ruser CB, Herold KC, Justice AC: Weight Gain and Incident Diabetes Among HIV-Infected Veterans Initiating Antiretroviral Therapy Compared With Uninfected Individuals. J Acquir Immune Defic Syndr. 2016 Oct 1. PMID: 27171741 Garyu JW, Meffre E, Cotsapas C, Herold KC: Progress and challenges for treating Type 1 diabetes. J Autoimmun. 2016 Jul; 2016 May 17. PMID: 27210268 Wilcox NS, Rui J, Hebrok M, Herold KC: Life and death of β cells in Type 1 diabetes: A comprehensive review. J Autoimmun. 2016 Jul; 2016 Mar 24. PMID: 27017348 Boyle KD, Keyes-Elstein L, Ehlers MR, McNamara J, Rigby MR, Gitelman SE, Weiner LJ, Much KL, Herold KC: Two- and Four-Hour Tests Differ in Capture of C-Peptide Responses to a Mixed Meal in Type 1 Diabetes. Diabetes Care. 2016 Jun; 2016 Apr 13. PMID: 27208317 Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC: Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem. 2016 May 20; 2016 Mar 18. PMID: 26994137 Gill RG, Pagni PP, Kupfer T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Bel Hani A, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT: A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2016 May; 2015 Dec 30. PMID: 26718498 Rui J, Deng S, Lebastchi J, Clark PL, Usmani-Brown S, Herold KC: Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Diabetologia. 2016 May; 2016 Feb 24. PMID: 26910463 Perdigoto AL, Chatenoud L, Bluestone JA, Herold KC: Inducing and Administering Tregs to Treat Human Disease. Front Immunol. 2015; 2016 Jan 22. PMID: 26834735 Tooley JE, Vudattu N, Choi J, Cotsapas C, Devine L, Raddassi K, Ehlers MR, McNamara JG, Harris KM, Kanaparthi S, Phippard D, Herold KC: Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes. Eur J Immunol. 2016 Jan; 2015 Dec 14. PMID: 26518356 Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q: Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25. PMID: 26606968 Herold KC, Majzoub JA, Melmed S, Pendergrass M, Schlumberger M: Endocrinology research-reflecting on the past decade and looking to the next. Nat Rev Endocrinol. 2015 Nov; 2015 Oct 13. PMID: 26460340 Wherrett DK, Chiang JL, Delamater AM, DiMeglio LA, Gitelman SE, Gottlieb PA, Herold KC, Lovell DJ, Orchard TJ, Ryan CM, Schatz DA, Wendler DS, Greenbaum CJ, Type 1 Diabetes TrialNet Study Group.: Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care. 2015 Oct. PMID: 26404927 Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, Skyler JS, Sosenko JM, Ziegler AG: Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 2015 Oct. PMID: 26404926 Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.: The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months. Diabetes Care. 2015 May; 2015 Mar 10. PMID: 25758770 Reed JC, Herold KC: Thinking bedside at the bench: the NOD mouse model of T1DM. Nat Rev Endocrinol. 2015 May; 2015 Jan 27. PMID: 25623120 Hughes J, Vudattu N, Sznol M, Gettinger S, Kluger H, Lupsa B, Herold KC: Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care. 2015 Apr. PMID: 25805871 Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP, Type 1 Diabetes TrialNet Study Group., Diabetes Prevention Trial-Type 1 Study Group.: A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care. 2015 Feb; 2014 Dec 17. PMID: 25519451