个人简介
PhD University of California, Berkeley, Chemistry (2010)
BS Massachusetts Institute of Technology, Chemistry (2005)
Postdoctoral Fellow Brigham and Women's Hospital/Harvard Medical School
研究领域
Bacteria; Biochemistry; Enzyme Activation; Gastrointestinal Diseases; Microbiology; Host-Pathogen Interactions
近期论文
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Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, and Waldor MK. (2016) “Chemoproteomic profiling of host and pathogen enzymes active in cholera,” Nat Chem Biol 12: 268.
Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, and Bertozzi CR. (2013) “Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase,” Proc Natl Acad Sci USA 110(52): E5069-77.
Hatzios SK, Ringgaard S, Davis BM, and Waldor MK. (2012) “Studies of dynamic protein-protein interactions in bacteria using Renilla luciferase complementation are undermined by nonspecific enzyme inhibition,” PLoS ONE 7(8): e43175.
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, and Bertozzi CR. (2009) “PapA3 is an acyltransferase required for Polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.” J Biol Chem 284: 12745-12751.
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK: Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 May 18. PMID: 27191648
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK: Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 Apr; 2016 Feb 22. PMID: 26900865
Wampande EM, Hatzios SK, Achan B, Mupere E, Nsereko M, Mayanja HK, Eisenach K, Boom WH, Gagneux S, Joloba ML, Tuberculosis Research Unit.: A single-nucleotide-polymorphism real-time PCR assay for genotyping of Mycobacterium tuberculosis complex in peri-urban Kampala. BMC Infect Dis. 2015 Sep 30; 2015 Sep 30. PMID: 26423522
Munera D, Ritchie JM, Hatzios SK, Bronson R, Fang G, Schadt EE, Davis BM, Waldor MK: Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nat Commun. 2014. PMID: 24445323
Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR: Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc Natl Acad Sci U S A. 2013 Dec 24; 2013 Dec 5. PMID: 24309377
Hatzios SK, Ringgaard S, Davis BM, Waldor MK: Studies of dynamic protein-protein interactions in bacteria using Renilla luciferase complementation are undermined by nonspecific enzyme inhibition. PLoS One. 2012; 2012 Aug 15. PMID: 22905225
Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi CR: The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 1; 2011 Jun 29. PMID: 21795043
Hatzios SK, Bertozzi CR: The regulation of sulfur metabolism in Mycobacterium tuberculosis. PLoS Pathog. 2011 Jul; 2011 Jul 21. PMID: 21811406
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR: PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2009 May 8; 2009 Mar 10. PMID: 19276083
Hatzios SK, Iavarone AT, Bertozzi CR: Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase. Biochemistry. 2008 May 27; 2008 May 3. PMID: 18454554