Hattangadi, Shilpa - Yale University - Biological & Biomedical Sciences

个人简介

Shilpa Hattangadi has an Electrical Engineering and Computer Science undergraduate degree from MIT. Her postdoctoral work at the Whitehead Institute in Harvey Lodish's lab spurred an interest in applying fundamental molecular biology to intriguing concenpts in red blood cell development. Her initial work on the dynamics of chromatin modifications during erythroid transcription transformed into a focus on erythroid nuclear development. Our laboratory now centers on the dynamics of chromatin during normal terminal erythroid differentiation, specifically chromatin condensation and enucleation, which is specific to mammalian red cell development, as well as the role of certain chromatin modifiers on erythroid nuclear development in diseases such as myelodysplastic syndrome (MDS). MD Duke University Medical Center, Medicine (1999) BS Massachusetts Institute of Technology, Electrical Engineering/Biology (1995) Postdoctoral Fellow Whitehead Institute for Biomedical Research Fellowship Boston Children's Hospital/Dana Farber Cancer Center Residency Johns Hopkins Hospital Board Certification AB of Pediatrics, Pediatric Hematology-Oncology (2006, recertified: 2014)

研究领域

Disease Models, Animal; Erythropoiesis; Hematologic Diseases; Hematopoiesis; Heterochromatin; Histone Deacetylases; Histones; Microscopy, Confocal; Nucleocytoplasmic Transport Proteins; Chromatin Immunoprecipitation; Erythroid-Specific DNA-Binding Factors

近期论文

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Histones to the cytosol: Exportin 7 is essential for normal terminal erythroid nuclear maturation. SM Hattangadi, S Martinez, HC Patterson, J Shi, KA Burke, AA Figueroa, S Venkatesan, J Wang, K Paulsen, D Gorlich, M Murata-Hori, and HF Lodish. Blood. 2014 Sep 18;124(12):1931-40. PMID: 25092175 Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Law TC, Vogin G, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, and BH Paw. Nature. 2012 Nov 22; 491(7425):608-12. Epub 2012 Nov 7. PMID: 23135403 Snx3 regulates recycling of the transferrin receptor and iron assimilation. Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, J. King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J,. Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, and BH Paw (2013). Cell Metab. 2013 Mar 5;17(3):343-52. Epub 2013 Feb 14. PMID: 23416069 From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins and RNAs (review). Hattangadi SM, Wong P, Zhang L, Flygare J, and HF Lodish (2011). Blood. 2011 Dec 8; 118(24):6258-68. Epub 2011 Oct 12. PMID: 21998215 Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Wong P*, Hattangadi SM*, Cheng AW, Frampton GW, Young RA, and HF Lodish (2011). Blood. 2011 Oct 20;118(16):e128-38. Epub 2011 Aug 22. PMID: 21860024 Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Hattangadi SM, Burke KA, and HF Lodish (2010). Blood, 2010 Jun 10; 115(23) 4853-61. Epub 2010 Mar 15. PMID: 20231426 Regulation of erythrocyte lifespan: do reactive oxygen species set the clock? Hattangadi SM, Lodish HF. J Clin Invest. 2007 Aug;117(8):2075-7. PMID: 17671642