Ha, Ya - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of Minnesota (1998) BS Nanjing University (1992) Postdoctoral Fellow Harvard University

研究领域

Alzheimer Disease; Membrane Proteins; Pharmacology; Crystallography, X-Ray; Chemicals and Drugs

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S’ subsites. Xue, Y., Chowdhury, S., Liu, X., Akiyama, Y., Ellman, J. & Ha, Y. (2012) Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S’ subsites. Biochemistry 51, 3723-3731. The catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate. Xue, Y. & Ha, Y. (2012) The catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate. J. Biol. Chem. 287, 3099-3107. The crystal structure of GXGD membrane protease FlaK. Hu, J., Xue, Y., Lee, S. & Ha, Y. (2011) The crystal structure of GXGD membrane protease FlaK. Nature 475, 528-531. Open-cap conformation of intramembrane protease GlpG. Wang, Y. & Ha, Y. (2007) Open-cap conformation of intramembrane protease GlpG. Proc. Natl. Acad. Sci. U.S.A. 104,2098-2102. The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. Wang, Y., Maegawa, S., Akiyama, Y. & Ha, Y. (2007) The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J. Mol. Biol. 374, 1104-1113. Crystal structure of a rhomboid family intramembrane protease. Wang, Y. Zhang, Y. & Ha, Y. (2006) Crystal structure of a rhomboid family intramembrane protease. Nature 444,179-183. Muftuoglu Y, Xue Y, Gao X, Wu D, Ha Y: Mechanism of substrate specificity of phosphatidylinositol phosphate kinases. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 20. PMID: 27439870 Hu J, Yuan Q, Kang X, Qin Y, Li L, Ha Y, Wu D: Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled. Nat Commun. 2015 Sep 14; 2015 Sep 14. PMID: 26365782 Kuo IY, Hu J, Ha Y, Ehrlich BE: Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels. J Biol Chem. 2015 Mar 6; 2015 Jan 21. PMID: 25609250 Xue Y, Ha Y: Large lateral movement of transmembrane helix S5 is not required for substrate access to the active site of rhomboid intramembrane protease. J Biol Chem. 2013 Jun 7; 2013 Apr 22. PMID: 23609444 Ha Y, Akiyama Y, Xue Y: Structure and mechanism of rhomboid protease. J Biol Chem. 2013 May 31; 2013 Apr 12. PMID: 23585569 Xue Y, Chowdhury S, Liu X, Akiyama Y, Ellman J, Ha Y: Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites. Biochemistry. 2012 May 8; 2012 Apr 24. PMID: 22515733 Xue Y, Ha Y: Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate. J Biol Chem. 2012 Jan 27; 2011 Nov 29. PMID: 22130671 Xue Y, Lee S, Ha Y: Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc Natl Acad Sci U S A. 2011 Sep 27; 2011 Sep 19. PMID: 21930949 Xue Y, Lee S, Wang Y, Ha Y: Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. J Biol Chem. 2011 Aug 26; 2011 Jun 29. PMID: 21715329 Hu J, Xue Y, Lee S, Ha Y: The crystal structure of GXGD membrane protease FlaK. Nature. 2011 Jul 17; 2011 Jul 17. PMID: 21765428 Lee S, Xue Y, Hu J, Wang Y, Liu X, Demeler B, Ha Y: The E2 domains of APP and APLP1 share a conserved mode of dimerization. Biochemistry. 2011 Jun 21; 2011 May 26. PMID: 21574595 Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, Ha Y: Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem. 2010 Jan 15; 2009 Nov 10. PMID: 19906646 Ha Y: Structure and mechanism of intramembrane protease. Semin Cell Dev Biol. 2009 Apr; 2008 Nov 19. PMID: 19059492