Ealick, Steven Edward - Cornell University - Department of Chemistry and Chemical Biology

研究领域

The Ealick group studies the structure and function of proteins using X-ray crystallography. The main goals of the research are to understand the structural basis of enzyme mechanism, to design small molecules of potential chemotherapeutic importance, to study the basis of protein evolution, and to expand the tools available to macromolecular crystallographers.

近期论文

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Mehta AP, Abdelwahed S, Mahanta N, Fedoseyenko D, Philmus B, Cooper L, Liu Y, Jhulki I, Ealick SE, and Begley TP. Radical SAM Enzymes in Cofactor Biosynthesis: a treasure trove of complex organic radical rearrangement reactions. J. Biol. Chem. 290: 3980-3986 (2015). Ye W, Paul D, Gao L, Seckute J, Sangaiah R, Jayaraj K, Zhang Z, Kaminski PA, Ealick SE, Gold A, and Ball LM. Ethenoguanines Undergo Glycosylation by Nucleoside 2'-Deoxyribosyltransferases at Non-Natural Sites. PLoS One 9:e115082 (2014). Abstract PubMed New structure of Purine 2'-Deoxyribosyltransferase Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, and Liu HW. Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis. Nature 510:427-431 (2014). (Reports structures of both BexX and BexX-CysO) Sikowitz MD, Shome B, Zhang Y, Begley TP, and Ealick SE. Structure of a Clostridium botulinum C143S thiaminase I/thiamin complex reveals active site architecture. Biochemistry 52:7830−7839 (2013). Soriano EV, Zhang Y, Colabroy K, Sanders JM, Settembre EC, Dorrestein PC, Begley TP, and Ealick SE. Active Site Models for Complexes of Quinolinate Synthase with Substrates and Intermediates. Acta Crystallogr. D. 69:1685–1696 (2013). Sikowitz MD, Cooper LE, Begley TP, Kaminski PA, and Ealick SE. Reversal of Substrate Specificity of CMP N-glycosidase to dCMP. Biochemistry 52:4037–4047 (2013). Abstract PubMed (Reports structures of both Clostridium botulinum BcmB and Saccharomyces rimofaciens MilB) Hicks KA, O'Leary SE, Begley TP, and Ealick SE. Structural and Mechanistic Studies of HpxO, a Novel FAD-dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry 52:477-487 (2013). Abstract PubMed Huang S, Mahanta N, Begley TP, and Ealick SE. Pseudouridine Monophosphate Glycosidase: A New Glycosidase Mechanism. Biochemistry 51:9245-9255 (2012). Knaus T, Eger E, Koop J, Stipsits S, Kinsland CL, Ealick SE, and Macheroux P. Reverse structural genomics: An unsual flavin binding site in a putative protease from Bacteroides thetaiotaomicron, J. Biol. Chem. 287:27490-27498 (2012). Abstract PubMed Lai RY, Huang S, Fenwick MK, Hazra AB, Zhang Y, Rajashankar KR, Philmus B, Kinsland C, Sanders JM, Ealick SE, and Begley TP. Thiamin pyrimidine biosynthesis in Candida albicans: a remarkable reaction between histidine and pyridoxal phosphate. J. Am. Chem. Soc. 134:9157−9159. (2012). Begley TP, Ealick SE, and McLafferty FW. Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochem. Soc. Trans. 40:555-60 (2012). Dessanti P, Zhang Y, Allegrini S, Tozzi MG, Sgarrella F, and Ealick SE. Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase. Acta Crystallogr. D 68:239-248 (2012). . Pdf. Reference Zhang Y, Zwart PH, and Ealick SE. A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II. Acta Crystallogr. D 68:249-252 (2012). . Pdf. Reference Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, and Begley TP. Identification of the product of Toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. J. Am. Chem. Soc. 134:5326-5330. (2012). Abstract PubMed Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, and Begley TP. Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature 478:542-6 (2011). Abstract PubMed Accompanying News & Views report Bale, S., and Ealick, S. E. (2011) Structural Biology in Polyamine Drug Discovery, in Polyamine Drug Discovery (Woster, P., and Casero, R., Eds.), RSC Publishing, Cambridge, UK. Abstract. URL Mukherjee T, Hanes J, Tews I, Ealick SE, and Begley TP. Pyridoxal phosphate: Biosynthesis and catabolism. Biochim. Biophys. Acta 1814:1585-1596 (2011). Seckute J, McCloskey DE, Thomas JH, Secrist III JA, Pegg AE, and Ealick SE. Binding and Inhibition of Human Spermidine Synthase by Decarboxylated S-adenosylhomocysteine. Protein Sci. 20:1836-1844 (2011). Abstract PubMed Tran TH, Krishnamoorthy K, Begley TP, and Ealick SE. A Novel Mechanism of Sulfur Transfer Catalyzed by O-Acetylhomoserine Sulfhydrylase in the Methionine Biosynthetic Pathway of Wolinella succinogenes. Acta Cryst. D 167:831-838 (2011). PDF Reference French JB, Begley TP, and Ealick SE. Structure of trifunctional THI20 from yeast. Acta Cryst. D 67:784-791 (2011).