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个人简介

PhD Boston University (2005)

研究领域

Cell Biology; Hematopoietic Stem Cells; Cellular Reprogramming

近期论文

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Choosing Cell Fate Through a Dynamic Cell Cycle Xinyue Chen , Amaleah Hartman and Shangqin Guo, Current Stem Cell Reports September 2015, Volume 1, Issue 3, pp 129-138 Non-stochastic reprogramming from a privileged somatic cell state. Non-stochastic reprogramming from a privileged somatic cell state. Shangqin Guo (corresponding author), Xiaoyuan Zi, Vincent P. Schulz, Jijun Cheng, Mei Zhong, Sebastian H.J. Koochaki, Cynthia M. Megyola, Xinghua Pan, Kartoosh Heydari, Sherman M. Weissman, Patrick G. Gallagher, Diane S. Krause, Rong Fan and Jun Lu. Cell, online Jan 30th, 2014 An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. Cheng J, Guo S (co-first and co-corresponding author), Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. Cell Rep. 2013 Oct 31;5(2):471-81. Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng EC, Nottoli T, Krause DS, Lu J, Guo S. Stem Cells. 2013 May;31(5):895-905. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16636-41. A microRNA regulating adult hematopoietic stem cells. A microRNA regulating adult hematopoietic stem cells. Guo S, Scadden DT. Cell Cycle. 2010 Sep 15;9(18):3637-8. MicroRNA miR-125a controls hematopoietic stem cell number. MicroRNA miR-125a controls hematopoietic stem cell number. Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14229-34. Compartmentalized organization: a common and required feature of stem cell niches? Compartmentalized organization: a common and required feature of stem cell niches? Greco V, Guo S. Development. 2010 May;137(10):1586-94. Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J: miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017 Mar 16; 2017 Jan 4. PMID: 28053194 Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J: A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nat Commun. 2016 Mar 30; 2016 Mar 30. PMID: 27025950 Guo S, Zi X, Schulz VP, Cheng J, Zhong M, Koochaki SH, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J: Nonstochastic reprogramming from a privileged somatic cell state. Cell. 2014 Feb 13; 2014 Jan 30. PMID: 24486105 Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J: An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep. 2013 Oct 31; 2013 Oct 10. PMID: 24120864 Nolde MJ, Cheng EC, Guo S, Lin H: Piwi genes are dispensable for normal hematopoiesis in mice. PLoS One. 2013; 2013 Aug 23. PMID: 24058407 Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng EC, Nottoli T, Krause DS, Lu J, Guo S: Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells. 2013 May. PMID: 23335078 Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J: An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. Cell Rep. 2012 Oct 25; 2012 Oct 19. PMID: 23084747 Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J: Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proc Natl Acad Sci U S A. 2012 Oct 9; 2012 Sep 24. PMID: 23012470 Guo S, Scadden DT: A microRNA regulating adult hematopoietic stem cells. Cell Cycle. 2010 Sep 15; 2010 Sep 28. PMID: 20855952 Greco V, Guo S: Compartmentalized organization: a common and required feature of stem cell niches? Development. 2010 May. PMID: 20430743

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