Grutzendler, Jaime - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Grutzendler obtained his MD at Universidad Javeriana in Bogota, Colombia where he was born and raised. He completed a medical internship in Internal Medicine and a residency in Neurology at Washington University/Barnes-Jewish Hospital in St. Louis. This was followed by a combined clinical and research fellowship in the Alzheimer Disease Research Center and the Department of Neurobiology at Washington University and further neurobiology research training at the Skirball Institute of New York University. Dr. Grutzendler's clinical interests focus on neurodegenerative disorders with special emphasis in dementias such as Alzheimer's disease. He also leads a research laboratory focused on understanding brain function and the cellular basis of neurological diseases. His lab uses advanced microscopy to visualize neurons, endothelium, astrocytes, pericytes, microglia and oligodendrocytes in living animals with the goal of exploring their dynamic behavior and learning how cell-cell interactions develop. He aims to understand how these interactions are disrupted in disease states such as in Alzheimer's disease, stroke and demyelination with the ultimate goal of designing new therapies for these conditions. MD Universidad Javeriana School of Medicine (1991) Postdoctoral Fellow Skirball Institute/New York University Research Fellow Washington University in St. Louis Clinical Fellow Washington University in St. Louis Resident Washington Univeristy in St. Louis Intern Washington University in St. Louis Board Certification AB of Psychiatry & Neurology, Neurology (2003, recertified: 2015)

研究领域

Alzheimer Disease; Astrocytes; Axons; Blood-Brain Barrier; Capillaries; Cerebrovascular Circulation; Microscopy; Nerve Fibers, Myelinated; Neuronal Plasticity; Regional Blood Flow; Microglia; Neurodegenerative Diseases; Pericytes

近期论文

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. Neuron. 2016 May 18;90(4):724-39. doi: 10.1016/j.neuron.2016.05.003. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. Yuan P, Grutzendler J. J Neurosci. 2016 Jan 13;36(2):632-41. doi: 0.1523/JNEUROSCI.2531-15.2016 Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J. Neuron. 2015 Jun 23. pii: S0896-6273 Microglia constitute a barrier that prevents neurotoxic protofibrillar Aß42 hotspots around plaques. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aß42 hotspots around plaques. Condello C, Yuan P, Schain A, Grutzendler J. Nature Comms. 2015 Jan 29;6 :6176. In vivo imaging of oligodendrocytes using sulforhodamine 101. In vivo imaging of oligodendrocytes using sulforhodamine 101. R. Hill and J. Grutzendler. Nature Methods, 2014. Oct 30;11:1081-1082. Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Schain A, Hill R, Grutzendler J. Nature Medicine. 2014 Mar 30; Epub 2014 Mar 30. Angiophagy prevents early embolus washout but leads to microvascular recanalization through embolus extravasation. Angiophagy prevents early embolus washout but leads to microvascular recanalization through embolus extravasation. Grutzendler J, Murikinati S, Hiner B ,Lam C , Yoo T ,Ji L, Hafler B, Adelman R ,Gupta S, Yuan P, Rodriguez G. Science Translational Medicine. 2014. 6:226-231 Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.C. Whiteus, C. Freitas, J. Grutzendler. Nature. 2013, Dec 04 .505, 407–411 In vivo imaging of cerebral microvascular plasticity from birth to death. In vivo imaging of cerebral microvascular plasticity from birth to death. Harb R, Whiteus C, Freitas C, Grutzendler J. J Cereb Blood Flow Metab. 2012 Oct 24. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. C. Condello, A. Schain, J. Grutzendler. Scientific Reports. 2011. 1,19. doi:10.1038/srep00019. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-ß phagocytosis. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-ß phagocytosis. Liu Z, Condello C, Schain A, Harb R, Grutzendler J. J Neurosci. 2010 Dec 15;30(50):17091-101. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Nature. 2010 May 27;465(7297):478-82. Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease.