Gruen, Jeffrey Robert - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Gruen received his BS and his MD degrees from Tulane University in New Orleans. He has been at Yale since beginning internship training in pediatrics in 1981, which was followed by subspecialty training in neonatology and research training in molecular genetics with Dr. Sherman Weissman. Dr. Gruen formally joined the faculty at Yale in 1988, splitting his time as a neonatology attending in the Newborn Intensive Care Unit (NICU) at Yale-New Haven Hospital and his lab where he initially mapped the gene for hemochromatosis. By 2000, the focus of his lab turned to mapping and identifying the reading disability (dyslexia) gene locus on chromosome 6 (DYX2). His lab was the first to generate high-resolution genetic markers, genetic association maps, and gene expression maps of DYX2. These studies led to the identification of DCDC2, a dyslexia gene that was cited by the journal Science as the 5th top breakthrough of 2005. The lab performed an NIH funded clinical study of DCDC2 and other genes related to reading and language in the ALSPAC birth cohort of 10,000 children and mothers. These studies identified the transcriptional control element called READ1, and READ1 alleles that are detrimental and protective for reading disability and language impairment. Dr. Gruen is the principal investigator for the Yale Genes, Reading and Dyslexia (GRaD) Study, a ground-breaking case-control study of dyslexia in 1,400 Hispanic American and African American children recruited from seven sites across North America. He was the Yale site PI for the NIH Pediatric Imaging NeuroGenetics (PING) Data Resource Study of 1,575 normal children, ages 3-20 years. Most recently, Dr. Gruen started the New Haven Lexinome Project, a new six-year longitudinal study of the genetics of response-to-intervention spanning the entire 2015 and 2016 New Haven Public Schools first grade classes. The goals of the New Haven Lexinome Project are to determine risk for learning disabilities conferred by specific genetic variants for presymptomatic diagnosis, and to determine how genetic variants inform intervention for precision/personal education. In addition to his research, Dr. Gruen continues to attend 8 weeks each year in the NICU at the Children’s Hospital at Yale-New Haven. MD Tulane University (1981) BS Tulane University, Chemistry (1977) Fellow Yale University School of Medicine, New Haven, CT Resident Yale-New Haven Hospital, New Haven, CT Intern Pediatrics, Yale-New Haven Hospital, New Haven, CT Board Certification AB of Pediatrics, Pediatrics (1986)

研究领域

Dyslexia; Genetics; Language; Language Development Disorders; Learning Disorders; Investigative Techniques; Neonatology; Pediatrics

近期论文

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Genome-Wide Association Study of Shared Components of Reading Disability and Language Impairment. Genes Brain Behav. Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ Jr, Dale AM, Jernigan TL, Pourcain BS, Smith GD, Ring SM, Gruen JR; for the Pediatric Imaging, Neurocognition Genetics Study. Genome-Wide Association Study of Shared Components of Reading Disability and Language Impairment. Genes Brain Behav. 2013 Sep 11. doi: 10.1111/gbb.12085. [Epub ahead of print] PMID: 24024963 [PubMed - as supplied by publisher] Connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments. Eicher JD, and Gruen JR. Imaging-Genetics in Dyslexia: Connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments. Molecular Genetics and Metabolism 2013 (http://dx.doi.org/10.1016/j.ymgme.2013.07.001, in press). Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment. *Powers NR, Eicher JD, Butter F, Kong Y, Miller LL, Ring SM, Mann M, Gruen JR. Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment. American Journal of Human Genetics 2013 Jul 11;93(1):19-28. PMID: 23746548 Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR. Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. PLoS One 2013 May 15;8(5):e63762. PMID: 23691092 PMCID: PMC3655151. Prenatal exposure to nicotine and impaired reading performance. Cho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal exposure to nicotine and impaired reading performance. J Pediatr. 2013 Apr;162(4):713-718.e2. PMID: 23122624. DCDC2 genetic variants and susceptibility to developmental dyslexia. Marino C, Meng H, Mascheretti S, Rusconi M, Cope N, Giorda, R Molteni M, and Gruen JR. DCDC2 genetic variants and susceptibility to developmental dyslexia. Psychiatric Genetics, 2012 22(1):25-30 PMID: 21881542 A dyslexia-associated variant in DCDC2 changes gene expression. Meng H, Powers NR, Tang L, Cope NA, Zhang P-X, Fuleihan R, Gibson C, Page GP, Gruen JR. A dyslexia-associated variant in DCDC2 changes gene expression. Behavior Genetics 2011 Jan;41(1):58-66 PMID: 21042874 Guideline for data analysis of genomewide association studies. Zhang H, Liu L, Wang X, Gruen JR. (2007). Guideline for data analysis of genomewide association studies. Cancer Genomics Proteomics. 4(1):27-34. Review. PMID: 17726238 Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. Cope N, Eicher JD, Meng H, Gibson CJ, Hager K, Lacadie C, Fulbright RK, Constable RT, Page GP, Gruen JR. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. Neuroimage. 2012 Jun 7;63(1):148-156. [Epub ahead of print] PMID: 22750057. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. (2005). DCDC2 is associated with reading disability and modulates neuronal development in the brain. Genetic approaches to complications of prematurity. Meng H and Gruen JR (2007) Genetic approaches to complications of prematurity, Frontiers in Bioscience, 12, 2344-2351, In Press