Groisman, Eduardo - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of Chicago (1986) MS University of Buenos Aires, Argentina (1980)

研究领域

Ecology; Biological Evolution; Genetics; Signal Transduction; Infectious Disease Medicine; Microbiota

近期论文

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A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase. A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase. Lee EJ, Pontes MH, Groisman EA. Cell. 2013 Jul 3;154(1):146-56. doi: 10.1016/j.cell.2013.06.004. The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa. The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa. Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9499-504. doi: 10.1073/pnas.1303420110. Epub 2013 May Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems. Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems. Townsend GE 2nd, Raghavan V, Zwir I, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jan 8110(2):E161-9. doi: 10.1073/pnas.1212102110. Epub 2012 Dec 19. Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA. Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA. Lee EJ, Groisman EA. Nature. 2012 Jun 13;486(7402):271-5. doi: 10.1038/nature11090. Yeom J, Wayne KJ, Groisman EA: Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate. Mol Cell. 2017 Apr 20. PMID: 28431231 Schwalm ND 3rd, Townsend GE 2nd, Groisman EA: Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Mol Microbiol. 2017 Apr; 2017 Feb 3. PMID: 28009067 Kriner MA, Groisman EA: RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader. Nucleic Acids Res. 2017 Jan 25; 2016 Oct 5. PMID: 28123036 Pontes MH, Yeom J, Groisman EA: Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress. Mol Cell. 2016 Nov 3; 2016 Oct 13. PMID: 27746019 Schwalm ND 3rd, Townsend GE 2nd, Groisman EA: Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron. MBio. 2016 Oct 11; 2016 Oct 11. PMID: 27729509 Groisman EA: Feedback Control of Two-Component Regulatory Systems. Annu Rev Microbiol. 2016 Sep 8. PMID: 27607549 Choi J, Groisman EA: Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence. Mol Microbiol. 2016 Sep; 2016 Jul 8. PMID: 27282333 Kriner MA, Sevostyanova A, Groisman EA: Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho. Trends Biochem Sci. 2016 Aug; 2016 Jun 17. PMID: 27325240 Sevostyanova A, Groisman EA: An RNA motif advances transcription by preventing Rho-dependent termination. Proc Natl Acad Sci U S A. 2015 Dec 15; 2015 Nov 16. PMID: 26630006 Kriner MA, Groisman EA: The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals. J Mol Biol. 2015 Dec 4; 2015 Oct 30. PMID: 26523680 Pontes MH, Sevostyanova A, Groisman EA: When Too Much ATP Is Bad for Protein Synthesis. J Mol Biol. 2015 Aug 14; 2015 Jul 4. PMID: 26150063 Raghavan V, Groisman EA: Species-specific dynamic responses of gut bacteria to a mammalian glycan. J Bacteriol. 2015 May; 2015 Feb 17. PMID: 25691527 Pontes MH, Lee EJ, Choi J, Groisman EA: Salmonella promotes virulence by repressing cellulose production. Proc Natl Acad Sci U S A. 2015 Apr 21; 2015 Apr 6. PMID: 25848006 Park SY, Pontes MH, Groisman EA: Flagella-independent surface motility in Salmonella enterica serovar Typhimurium. Proc Natl Acad Sci U S A. 2015 Feb 10; 2015 Jan 26. PMID: 25624475 Zwir I, Yeo WS, Shin D, Latifi T, Huang H, Groisman EA: Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing. MBio. 2014 Oct 7; 2014 Oct 7. PMID: 25293763 Hollands K, Sevostiyanova A, Groisman EA: Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator. Proc Natl Acad Sci U S A. 2014 May 13; 2014 Apr 28. PMID: 24778260