Greco, Valentina - Yale University - Biological & Biomedical Sciences

个人简介

Valentina Greco was born in Palermo, Italy and earned her undergraduate degree in Molecular Biology at the University of Palermo, Italy. She earned her PhD with Suzanne Eaton at the EMBL/MPI-CBG, Germany (1998-2002) and her post-doc with Elaine Fuchs at the Rockefeller University (2003-2009). Dr. Greco is currently an Associate Professor in the Genetics, Cell Biology and Dermatology Departments, and a member of the Yale Stem Cell Center and Yale Cancer Center at the Medical School of Yale University (2009-present). PhD Heidelberg University (2002) BS University of Biological Science, Palermo, Italy (1996) Post-doctoral Associate Rockefeller University

研究领域

Cell Biology; Dermatology; Genetics; Neoplasms by Histologic Type; Regeneration; Stem Cells; Stem Cell Niche

近期论文

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Spatiotemporal coordination of stem cell commitment during epidermal homeostasis Rompolas P*, Mesa K*, Kawaguchi K, Park S, Gonzalez S, Brown S, Boucher J, Klein AM*, Greco V* DOI: 10.1126/science.aaf7012 Intravital imaging of hair follicle regeneration in the mouse. Pineda CM#, Park S#, Mesa KR, Wolfel M, Gonzalez D, Haberman A, Rompolas P*, and Greco V*. Intravital imaging of hair follicle regeneration in the mouse. Nature Protocols. 2015 Jul 10(7):1116-30 Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez D, Blagoev K, Haberman A and Greco V*. Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature. 2015 Jun 4;522(7554):94-7 ß-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Deschene RE*, Myung P*, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I and Greco V*. 2014. ß-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Science. (* corresponding author; # equal contribution). PMID 24653033. Spontaneous tumor regression in keratoacanthomas is driven by Wnt /Retinoic Acid signaling cross-talk. Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ and Greco V*. 2014. Spontaneous tumor regression in keratoacanthomas is driven by Wnt /Retinoic Acid signaling cross-talk. Nature Communications. (* corresponding author). PMID 24667544. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging. Brown S and Greco V. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging. Cell Stem Cell 2014. Greco V. Establishing an academic laboratory: mentoring as a business model. 2014 Molecular Biology of the Cell. Linking morphogen and chromatin in the hair follicle Mesa Kailin R and Greco, Valentina#. 2013. “Linking morphogen and chromatin in the hair follicle”. Dev Cell. 29;25(2):113-4 .(# corresponding author). Stem cell dynamics in the hair follicle niche. Rompolas P* and Greco V*. 2013. Stem cell dynamics in the hair follicle niche. Semin Cell Dev Biol. Dec 17. * corresponding authors Spatial organization within a niche as a determinant of stem cell fate Rompolas P, Mesa KR and Greco V*. Spatial organization within a niche as a determinant of stem cell fate. Nature. 2013 Oct 24;502(7472):513-8 In vivo live imaging of stem cell and progeny behaviour in physiological hair follicle regeneration Rompolas, P., Deschene, E., Zito, G., Gonzalez, D., Saotome, I., Haberman, A., and Greco, V.*. “In vivo live imaging of stem cell and progeny behaviour in physiological hair follicle regeneration”. Nature. Jul 26. 2012. (* corresponding author). The death and growth connection Greco, V. The death and growth connection. Nat Rev Mol Cell Biol. 2012. 14(1):6. PMID: 23212474 Compartmentalized organization: a common and required feature of stem cell niches? Greco, V.* and Guo, S. “Compartmentalized organization: a common and required feature of stem cell niches?”. Development. 2010. 137(10):1586-94. (* corresponding author) A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration