Gorelick, Fred - Yale University - Biological & Biomedical Sciences

个人简介

After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examine the enzyme's mechanism of activation, a response critical to neuronal memory. His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He has also been the Director of the Yale Program in Investigative Gastroenterology for over 10 years. His laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease. MD University of Missouri (1973) Visiting Scientist Rockefeller University Post Doctoral Yale University GI Fellow Yale University School of Medicine Resident University of Missouri

研究领域

Autophagy; Cell Biology; Digestive System Diseases; Gastrointestinal Diseases; Pancreatic Diseases; Pancreatitis; Pancreas, Exocrine; AMP-Activated Protein Kinases; Proteolysis

近期论文

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Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS. PLoS One. 2012;7(7):e41320 Low extracellular pH modulates calcium signaling in the pancreatic acinar cell. Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH. Low extracellular pH modulates calcium signaling in the pancreatic acinar cell. J. Biological Chemistry 2011 286(3):1919-26 PMC330423 Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats. Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats. Gastroenterology. 137: 1083-1092, 2009 Vacuolar ATPase regulates zymogen activation in pancreatic acini. Waterford, S., Kolodecik, T., Thrower, E., and Gorelick, F. (2005). Vacuolar ATPase regulates zymogen activation in pancreatic acini. J. Biol. Chem. 280(7):5430-4. Regulation of zymogen processing in acinar cells by the ryanodine receptor. S. Husain, T. Kolodecik, M. Nathanson, F. Gorelick. Regulation of zymogen processing in acinar cells by the ryanodine receptor. Proc Natl Acad Sci, USA. 2005 102:14386-91 Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ. Gastroenterology. 2014 Jun;146(7):1763-74. Low pH enhances connexin32 degradation in the pancreatic acinar cell Reed AM, Kolodecik T, Husain SZ, Gorelick FS.Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G24-32 Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE. Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):695-709 Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV. Sci Rep. 2016 Mar 14;6:22996.