Goodman, Andrew - Yale University - Biological & Biomedical Sciences

个人简介

PhD Harvard Medical School (2006) BA Princeton University, Ecology and Evolutionary Biology (1999) Postdoctoral Researcher Washington University School of Medicine

研究领域

Bacteria; Germ-Free Life; Symbiosis; Genomics; Microbial Consortia; Microbiota

近期论文

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Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Wexler, A.W., Bao, Y., Whitney, J.C., Bobay, L-M., Xavier, J.B., Schofield, W.B., Barry, N.A., Russell, A.B., Tran, B.Q., Goo, Y., Goodlett, D.R., Ochman, H.O., Mougous, J.D., and Goodman, A.L. Proceedings of the National Academy of Sciences 133(13) p3639-44 (2016). Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation. Cullen, T.W., Schofield, W.B., Barry, N.A., Putnam, E.E., Rundell, E.A., Trent, M.S., Degnan, P.H., Booth, C.J., Yu, H., and Goodman, A.L. Science 347(6218) p170-175 (2015). Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Palm, N.W., de Zoete, M.R., Cullen, T.W., Barry, N.A., Stefanowski, J., Hao, L., Degnan, P.H., Hu, J., Peter, I., Zhang, W., Ruggiero, E., Cho, J.H., Goodman, A.L., and Flavell, R.A. Cell 158(5) p1000-1010 (2014). Human gut microbes use multiple transporters to distinguish vitamin B12 analogs and compete in the gut. Degnan, P.H., Barry, N.A., Mok, K.C., Taga, M.E., and Goodman, A.L. Cell Host & Microbe 15 p47-57 (2014). Experimental approaches for defining functional roles of microbes in the human gut. Dantas, G., Sommer, M.O.A., Degnan, P.H., and Goodman, A.L. Annual Reviews Microbiology 67 p459-75 (2013). Wexler AG, Goodman AL: An insider's perspective: Bacteroides as a window into the microbiome. Nat Microbiol. 2017 Apr 25; 2017 Apr 25. PMID: 28440278 Lim B, Zimmermann M, Barry NA, Goodman AL: Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut. Cell. 2017 Apr 20. PMID: 28431252 Raymann K, Moeller AH, Goodman AL, Ochman H: Unexplored Archaeal Diversity in the Great Ape Gut Microbiome. mSphere. 2017 Jan-Feb; 2017 Feb 22. PMID: 28251182 Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI: Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 2016 Jun 9. PMID: 27279214 Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL: Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proc Natl Acad Sci U S A. 2016 Mar 29; 2016 Mar 8. PMID: 26957597 Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ: Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nat Biotechnol. 2015 Dec; 2015 Nov 16. PMID: 26571098 Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC: Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. 2015 Nov 17; 2015 Nov 3. PMID: 26546281 Brooks JF 2nd, Gyllborg MC, Cronin DC, Quillin SJ, Mallama CA, Foxall R, Whistler C, Goodman AL, Mandel MJ: Global discovery of colonization determinants in the squid symbiont Vibrio fischeri. Proc Natl Acad Sci U S A. 2014 Dec 2; 2014 Nov 17. PMID: 25404340 Degnan PH, Taga ME, Goodman AL: Vitamin B12 as a modulator of gut microbial ecology. Cell Metab. 2014 Nov 4; 2014 Nov 4. PMID: 25440056 Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA: Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell. 2014 Aug 28. PMID: 25171403 Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD: A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism. Cell Host Microbe. 2014 Aug 13; 2014 Jul 25. PMID: 25070807 Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE: Novel components of the flagellar system in epsilonproteobacteria. MBio. 2014 Jun 24; 2014 Jun 24. PMID: 24961693 Degnan PH, Barry NA, Mok KC, Taga ME, Goodman AL: Human gut microbes use multiple transporters to distinguish vitamin B₁₂ analogs and compete in the gut. Cell Host Microbe. 2014 Jan 15. PMID: 24439897 Goodman AL, Wu M, Gordon JI: Identifying microbial fitness determinants by insertion sequencing using genome-wide transposon mutant libraries. Nat Protoc. 2011 Nov 17; 2011 Nov 17. PMID: 22094732