Gelernter, Joel - Yale University - Biological & Biomedical Sciences

个人简介

MD SUNY Downstate Medical Center (1983) BS Yale University (1979) Fellowship Psychiatric genetics, NIMH

研究领域

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

近期论文

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Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA. (2014) Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, and Gelernter J (2011) Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Wang Q, Yang C, Gelernter J, Zhao H. Hum Genet. Sep 4. Dissecting ancestry genomic background in substance dependence genome-wide association studies. Polimanti R, Yang C, Zhao H, Gelernter J. Pharmacogenomics. 2015 Aug;16(13):1487-98. doi: 10.2217/pgs.15.91. Epub 2015 Aug 12. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. Mol Psychiatry. 2016 Apr 12. doi: 10.1038/mp.2016.43. [Epub ahead of print] Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. Polimanti R, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2016 Oct;41(11):2688-96. doi: 10.1038/npp.2016.72. Epub 2016 May 17. Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Biol Psychiatry. 2015 Mar 1;77(5):493-503. doi: 10.1016/j.biopsych.2014.08.025. Epub 2014 Sep 16 Justice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR: Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcohol Clin Exp Res. 2017 May; 2017 Apr 10. PMID: 28295416 Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D, Collaborative Study of the Genetics of Alcoholism Consortium., Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, German Study of the Genetics of Addiction Consortium., Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP: Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Alcohol Clin Exp Res. 2017 May; 2017 Mar 30. PMID: 28226201 Polimanti R, Jensen KP, Gelernter J: Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. Sci Rep. 2017 Apr 21; 2017 Apr 21. PMID: 28432340 Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J: S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. J Psychiatry Neurosci. 2017 Apr 13; 2017 Apr 13. PMID: 28418321 Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J: Sex-specific linkage scans in opioid dependence. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr; 2016 Oct 20. PMID: 27762075 Polimanti R, Gelernter J: ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet. 2017 Mar 27; 2017 Mar 27. PMID: 28349588 Polimanti R, Agrawal A, Gelernter J: Schizophrenia and substance use comorbidity: a genome-wide perspective. Genome Med. 2017 Mar 21; 2017 Mar 21. PMID: 28327175 Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J: Genome-wide association study of body mass index in subjects with alcohol dependence. Addict Biol. 2017 Mar; 2015 Oct 12. PMID: 26458734 Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J, Army STARRS Collaborators.: Genetic risk variants for social anxiety. Am J Med Genet B Neuropsychiatr Genet. 2017 Mar. PMID: 28224735 Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB: Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. J Neurotrauma. 2017 Feb 15; 2016 Aug 25. PMID: 27439997