Geibel, John P - Yale University - Biological & Biomedical Sciences

个人简介

John Geibel is Vice Chairman of the Department of Surgery at Yale University School of Medicine and Director of Surgical Research and Professor of Cellular and Molecular Physiology. His early research training was in Innsbruck Austria where he worked in the Physiology Department and investigated renal physiology on the isolated perfused tubule model. He holds a Bachelors of Science Degree in Physiology, an MD and DSc degree as well as a Master’s of Science, and a Master’s of Arts Degree. He has also obtained his Dozent in Medicine from the University of Innsbruck. After obtaining his Dozent he went to Yale University first as a visiting fellow and then joined the faculty in both Surgery and Cellular and Molecular Physiology where he rose through the ranks to Professor in both faculties. Academically, Professor Geibel’s active research interests are on the role of the Calcium Sensing Receptor (CaSR) in gastrointestinal physiology and pathophysiology. In addition, John Geibel has conducted research in fluid and electrolyte transport in the intestine where he was the first to identify that the colonic crypt can both actively secrete and absorb fluid. He has also identified 4 new transport pathways in the stomach that play important roles in acid secretion and may help to explain some of the hypersecretion of acid that occurs in patients. In addition he maintains a research program in the kidney where he was the first to identify a functional role for the H-ATPase in the proximal tubule; he was also the first to demonstrate a role for Angiotensin on the Na/H exchanger and Na/HCO3 and H-ATPase in the proximal tubule. Professor Geibel is the author of over 150 publications and presents his findings both nationally and internationally. He is the holder of 7 patents on the role of the calcium sensing receptor on gastrointestinal models and is currently actively working to begin clinical trials on a method to stop secretory diarrhea in the developing world based on targeting the calcium sensing receptor. MD University of Innsbruck (1986) DSc University of Innsbruck (1983) MS University of New Brunswick, Physiology (1981)

研究领域

Diarrhea; Electrophysiology; Gastric Acid; Gastroenterology; Physiology

近期论文

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Effect of NSAIDs on Na+/H+ exchanger activity in Rat colonic crypts Roginiel AC, Kohut DL, Kaur S, Saleh AM, Weber T, Geibel P, Singh H, and Geibel JP. Effect of NSAIDs on Na+/H+ exchanger activity in Rat colonic crypts. American journal of physiology Cell physiology 2013 Gastric acid, calcium absorption, and their impact on bone health. Kopic S, and Geibel JP. Gastric acid, calcium absorption, and their impact on bone health. Physiological reviews 93: 189-268, 2013. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, and Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney international 2013. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, and Geibel JP. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflugers Archive : European journal of physiology 463: 419-427, 2012. Functional role of NHE4 as a pH regulator in rat and human colonic crypts Arena EA, Longo WE, Roberts KE, Geibel P, Nateqi J, Brandstetter M, and Geibel JP. Functional role of NHE4 as a pH regulator in rat and human colonic crypts. American journal of physiology Cell physiology 302: C412-418, 2012 Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, and Geibel JP. Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. The American journal of gastroenterology 106: 62-70, 2011. AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP: Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. J Am Coll Surg. 2016 Dec 23; 2016 Dec 23. PMID: 28017811 Munoz-Abraham AS, Judeeba S, Alkukhun A, Alfadda T, Patron-Lozano R, Rodriguez-Davalos MI, Geibel JP: A new method to measure intestinal secretion using fluorescein isothiocyanate-inulin in small bowel of rats. J Surg Res. 2015 Aug; 2015 Apr 20. PMID: 25976849 Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP: Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflugers Arch. 2015 Jul; 2014 Aug 17. PMID: 25127675 McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME: Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nat Commun. 2015 Apr 27; 2015 Apr 27. PMID: 25914116 Alfadda TI, Saleh AM, Houillier P, Geibel JP: Calcium-sensing receptor 20 years later. Am J Physiol Cell Physiol. 2014 Aug 1; 2014 May 28. PMID: 24871857 Collaco AM, Geibel P, Lee BS, Geibel JP, Ameen NA: Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. Am J Physiol Cell Physiol. 2013 Nov 1; 2013 Aug 28. PMID: 23986201 Roginiel AC, Kohut DL, Kaur S, Saleh AM, Weber T, Geibel P, Singh H, Geibel JP: Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts. Am J Physiol Cell Physiol. 2013 Sep; 2013 Jun 5. PMID: 23739181 Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM: Identification of functionally distinct Na-HCO3 co-transporters in colon. PLoS One. 2013; 2013 May 14. PMID: 23690961 Kopic S, Geibel JP: Gastric acid, calcium absorption, and their impact on bone health. Physiol Rev. 2013 Jan. PMID: 23303909 Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, Geibel JP: Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflugers Arch. 2012 Mar; 2011 Nov 17. PMID: 22146938 Arena EA, Longo WE, Roberts KE, Geibel P, Nateqi J, Brandstetter M, Geibel JP: Functional role of NHE4 as a pH regulator in rat and human colonic crypts. Am J Physiol Cell Physiol. 2012 Jan 15; 2011 Nov 2. PMID: 22049213 Shenoy A, Kopic S, Murek M, Caputo C, Geibel JP, Egan ME: Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages. Pediatr Res. 2011 Nov. PMID: 21796019 Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, Geibel JP: Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. Am J Gastroenterol. 2011 Jan; 2010 Aug 24. PMID: 20736941