Galan, Jorge E - Yale University - Biological & Biomedical Sciences

个人简介

PhD Cornell University (1986) DVM National University of La Plata, Argentina (1980) Postdoctoral fellow Washington University

研究领域

Bacteriology; Genetics, Microbial; Microbiology

近期论文

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Chaperone release and unfolding of substrates in type III secretion. Akeda Y, Galan JE. (2005). Chaperone release and unfolding of substrates in type III secretion. Nature 437: 911-915. Assembly of the inner rod determines needle length in the type III secretion injectisome Marlovitz, T.C., Kubori, T., Lara-Tejero, M., Thomas, D.R., Unger, V.M., and Galán, J.E. (2006). Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature 441(7093):637-40. Metabolic diversity in Campylobacter jejuni enhances specific tissue colonization Hofreuter, D., Novik, V., and J. E. Galán. 2008. Metabolic diversity in Campylobacter jejuni enhances specific tissue colonization. Cell Host & Microbe 4(5):425-33 Diversification of a Salmonella virulence effector protein function by ubiquitin-dependent differential localization Patel, J. C., Hueffer, K., Lam, T. T. , J. E. Galán. 2009. Diversification of a Salmonella virulence effector protein function by ubiquitin-dependent differential localization. Cell 137(2):283-94. A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems Lara-Tejero, M., J. Kato, S. Wagner, X. Liu, and J. E. Galán. 2011. A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems. Science 331: 1188-1191. A Rab32-depdent pathway controls Salmonella Typhi host restriction Spano, S. and J. E. Galán. 2012. A Rab32-depdent pathway controls Salmonella Typhi host restriction. Science 338:960-963. Conferring virulence: structure and function of the chimeric A2B5 typhoid toxin Song, J., X. Gao, and J. E. Galán. 2013. Conferring virulence: structure and function of the chimeric A2B5 typhoid toxin. Nature 499, 350–354. Hu B, Lara-Tejero M, Kong Q, Galán JE, Liu J: In Situ Molecular Architecture of the Salmonella Type III Secretion Machine. Cell. 2017 Mar 9. PMID: 28283062 Fowler CC, Chang SJ, Gao X, Geiger T, Stack G, Galán JE: Emerging insights into the biology of typhoid toxin. Curr Opin Microbiol. 2017 Feb 14; 2017 Feb 14. PMID: 28213043 Dietsche T, Tesfazgi Mebrhatu M, Brunner MJ, Abrusci P, Yan J, Franz-Wachtel M, Schärfe C, Zilkenat S, Grin I, Galán JE, Kohlbacher O, Lea S, Macek B, Marlovits TC, Robinson CV, Wagner S: Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus. PLoS Pathog. 2016 Dec; 2016 Dec 15. PMID: 27977800 Chang SJ, Song J, Galán JE: Receptor-Mediated Sorting of Typhoid Toxin during Its Export from Salmonella Typhi-Infected Cells. Cell Host Microbe. 2016 Nov 9. PMID: 27832592 Galán JE: Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi. Proc Natl Acad Sci U S A. 2016 Jun 7; 2016 May 24. PMID: 27222578 Zilkenat S, Franz-Wachtel M, Stierhof YD, Galán JE, Macek B, Wagner S: Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach. Mol Cell Proteomics. 2016 May; 2016 Feb 21. PMID: 26900162 Kamanova J, Sun H, Lara-Tejero M, Galán JE: The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members. PLoS Pathog. 2016 Apr; 2016 Apr 8. PMID: 27058235 Sun H, Kamanova J, Lara-Tejero M, Galán JE: A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis. PLoS Pathog. 2016 Mar; 2016 Mar 2. PMID: 26933955 Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F: Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell. 2016 Feb 25. PMID: 26919416 Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC: Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. J Am Chem Soc. 2016 Feb 24; 2016 Feb 16. PMID: 26847396 Spanò S, Gao X, Hannemann S, Lara-Tejero M, Galán JE: A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP. Cell Host Microbe. 2016 Feb 10. PMID: 26867180