Flavell, Richard A - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Flavell is Sterling Professor of Immunobiology at Yale University School of Medicine, and an Investigator of the Howard Hughes Medical Institute. He received his B.Sc. (Honors) in 1967 and Ph.D. in 1970 in biochemistry from the University of Hull, England, and performed postdoctoral work in Amsterdam (1970-72) with Piet Borst and in Zurich (1972-73) with Charles Weissmann. Before accepting his current position in 1988, Dr. Flavell was first Assistant Professor (equivalent) at the University of Amsterdam (1974-79); then Head of the Laboratory of Gene Structure and Expression at the National Institute for Medical Research, Mill Hill, London (1979-82); and subsequently President and Chief Scientific Officer of Biogen Research Corporation, Cambridge, Massachusetts (1982-88). Dr. Flavell is a fellow of the Royal Society, a member of the National Academy of Sciences as well as the Institute of Medicine. Richard Flavell uses transgenic and gene-targeted mice to study Innate and Adaptive immunity, T cell tolerance and activation in immunity and autoimmunity,apoptosis, and regulation of T cell differentiation. PhD Hull University (1970) EMBO Postdoctoral Fellow with Prof. C. Weissmann Universitat Zurich Postdoctoral Fellow with Professor Piet Borst University of Amsterdam

研究领域

Biology; Diabetes Mellitus; DNA, Recombinant; Immune System; Immunity; Lyme Disease; Autoimmunity; Gene Expression; Gene Transfer Techniques; Mice, Knockout; Cell Lineage; Lyme Neuroborreliosis

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease. Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL and Flavell RA: Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease. Cell. 2014 Aug 28;158 (5) :1000-10. PMID: 25171403 NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB and Flavell RA: NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014 Feb 27;156 (5) :1045-59. PMID: 24581500 Development and function of human innate immune cells in a humanized mouse model Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG and Flavell RA: Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol. 2014 Apr;32 (4) :364-72. Epub 2014 Mar 16. PMID: 24633240 Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota Gagliani N, Palm NW, de Zoete MR and Flavell RA: Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. Int Immunol. 2014 Sep;26 (9) :495-499. Epub 2014 Jun 19. PMID: 24948595 miR-181 is a cellular metabolic rheostat essential for NKT cell development Henao-Mejia J.*, Williams A*, Goff L.A., Staron M, Licona-Limón P, Kaech S.M., Nakayama M, Rinn J.L., Flavell R.A. miR-181 is a cellular metabolic rheostat essential for NKT cell development. Immunity. (2013). PMC3738211 IL-22BP axis is regulated by the inflammasome and modulates tumorogenesis in the intestine. Huber S, Gagliani N, Zenewicz LA, Huber FJ, Hedl W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA IL-22BP axis is regulated by the inflammasome and modulates tumorogenesis in the intestine. Nature Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez J-P, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. NLRP6 inflammasome is a regulator of the colonic microbial ecology and risk for colitis Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome is a regulator of the colonic microbial ecology and risk for colitis. Cell 145:745-757 (2011) May 27. PMC3140910 Control of TH17 cells occurs in the small intestine. Esplugues E1, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. (2011) Esplugues E1, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Unraveling the genetics of autoimmunity Zenewicz LA, Abraham C, Flavell RA, Cho JH. Unraveling the genetics of autoimmunity. Cell 140:791-797 (2010). The polarization of immune cells in the tumour environment of TGFb Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limon P. The polarization of immune cells in the tumour environment of TGFb. Nat. Rev. Immunol. 10:554-567 (2010). The dual-nature of TH17 cells: shifting focus to function O’Connor W Jr., Zenewicz LA, Flavell RA. Perspective. The dual-nature of TH17 cells: shifting focus to function. Nat. Immunol. 11:471-476 (2010). Requirement for AHNAK1 mediated calcium signaling during T lymphocyte cytolysis