Fikrig, Erol - Yale University - Biological & Biomedical Sciences

个人简介

My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils. We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission. MD Cornell University (1985) BA Cornell University (1981) Resident Vanderbilt University Hospital Fellow Yale University School of Medicine Board Certification AB of Internal Medicine, Internal Medicine (1988)

研究领域

Bacteria; Epidemiology; Lyme Disease; Parasitology; Public Health; Ticks; Viruses; West Nile virus; Global Health; Ehrlichiosis; Borrelia burgdorferi; Infectious Disease Medicine

近期论文

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The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity Silver, A.C., A. Arjona, W.E. Walker, and E. Fikrig. 2012. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 36:251-261. 3315694 A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent Schuijt, T.J., J. Coumou, S. Narasimhan, J. Dai, K. Deponte, D. Wouters, M. Brouwer, A. Oei, J.J. Roelofs, A.P. van Dam, T. van der Poll, C. Van't Veer, J.W. Hovius, and E. Fikrig. 2011. A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host Microbe 10:136-146. 3170916 A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes Cheng, G., J. Cox, P. Wang, M.N. Krishnan, J. Dai, F. Qian, J.F. Anderson, and E. Fikrig. 2010. A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes. Cell 142:714-725. 2954371 Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I Wang, P., A. Arjona, Y. Zhang, H. Sultana, J. Dai, L. Yang, P.M. LeBlanc, K. Doiron, M. Saleh, and E. Fikrig. 2010. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol 11:912-919. RNA interference screen for human genes associated with West Nile virus infection Krishnan M, Ng A, Sukumaran B, Gilfoy F, Uchil P, Sultana H, Brass A, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason P, Koski R, Elledge S, Xavier R, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 455, 425-5, 2008. Increased TLR4 expression and Innate Cytokine Production in Immunosuppressed Adults with Autoimmune Diseases Dunne, D. W., A. C. Shaw, L. K. Bockenstedt, H. Allore, S. Chen, S. E. Malawista, L. Leng, Y. Mizue, M. Piecychna, L. Zhang, V. Towle, R. Bucala, R. R. Montgomery, and E. Fikrig. 2010. Increased TLR4 expression and Innate Cytokine Production in Immunosuppressed Adults with Autoimmune Diseases. PLoS ONE 5(6): e11343. doi:10.1371/journal.pone.0011343 A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission. Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E. PLoS Pathog. 2014 Aug 7;10(8):e1004278. doi: 10.1371/journal.ppat.1004278. eCollection 2014 Aug. Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath T, Iwasaki A, Fikrig E: Sexual transmission of ZIKV causes fetal growth restriction in mice. J Infect Dis. 2017 May 2; 2017 May 2. PMID: 28472297 Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E: A tick antivirulence protein potentiates antibiotics against Staphylococcus aureus. Antimicrob Agents Chemother. 2017 Apr 24; 2017 Apr 24. PMID: 28438938 Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A: TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Rep. 2017 Apr 18. PMID: 28423319 Ansari JM, Abraham NM, Massaro J, Murphy K, Smith-Carpenter J, Fikrig E: Anti-Biofilm Activity of a Self-Aggregating Peptide against Streptococcus mutans. Front Microbiol. 2017; 2017 Mar 24. PMID: 28392782 Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E: Zika virus causes testicular atrophy. Sci Adv. 2017 Feb; 2017 Feb 22. PMID: 28261663 Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH: Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nat Commun. 2017 Feb 14; 2017 Feb 14. PMID: 28195158 Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE: Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS Pathog. 2017 Feb; 2017 Feb 2. PMID: 28152074 Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S: Zika virus infection of Hofbauer cells. Am J Reprod Immunol. 2017 Feb; 2016 Dec 14. PMID: 27966815 Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E: Pathogen-mediated manipulation of arthropod microbiota to promote infection. Proc Natl Acad Sci U S A. 2017 Jan 31; 2017 Jan 17. PMID: 28096373 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F: Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol. 2017 Jan 1; 2016 Dec 16. PMID: 27795421 Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F: TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. J Immunol. 2016 Dec 1; 2016 Oct 21. PMID: 27798161