Eswarakumar, Jacob V.P. - Yale University - Biological & Biomedical Sciences

个人简介

PhD Madurai Kamaraj University, Department of Immunology. (1999) Postdoctoral Fellow Weizmann Institute of Science Postdoctoral Associate Yale University

研究领域

Signal Transduction; Drug Discovery

近期论文

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FGFR2c-mediated ERK-MAPK activity regulates coronal suture development Pfaff MJ, Xue K, Li L, Horowitz MC, Steinbacher DM, Eswarakumar JV. FGFR2c-mediated ERK-MAPK activity regulates coronal suture development. Developmental Biology 415(2):242-50 (2016). FGFR2 mutation in 46,XY sex reversal with craniosynostosis Bagheri-Fam S, et al. FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Human Molecular Genetics. 24:6699-710 (2015). Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor-3 Eswarakumar VP and Schlessinger J. Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor-3. Proc Natl Acad Sci U S A. 104:3937-42 (2007) Distinct target-derived signals organize formation, maturation and maintenance of motor nerve terminals Fox MA, et al. Distinct target-derived signals organize formation, maturation and maintenance of motor nerve terminals. Cell 129:179-93 (2007) Attenuation of signaling pathways stimulated by pathologically activated FGFR2 mutants prevents craniosynostosis Eswarakumar VP, et.al. Attenuation of signaling pathways stimulated by pathologically activated FGFR2 mutants prevents craniosynostosis. Proc Natl Acad Sci U S A. 103:18063-8 (2006) Mutations in different components of FGF-signalling in LADD syndrome Rohmann E, et al. Mutations in different components of FGF-signalling in LADD syndrome. Nature Genetics 38:414-417 (2006) A gain of function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis Eswarakumar VP, Horowitz MC, Locklin R, Morriss-Kay GM and Lonai P. A gain of function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A. 101:12555-60 (2004) The IIIc alternative of Fgfr2 is a positive regulator of bone formation Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P. The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 129: 3783-93 (2002) Lin Y, Gao H, Ai S, Eswarakumar JV, Li T, Liu B, Jiang H, Liu Y, Liu X, Li Y, Ni Y, Chen J, Lin Z, Liang X, Jin C, Huang X, Lu L, Liu Y: Molecular analysis of FGFR 2 and associated clinical observations in two Chinese families with Crouzon syndrome. Mol Med Rep. 2016 Sep; 2016 Jul 11. PMID: 27430617 Pfaff MJ, Xue K, Li L, Horowitz MC, Steinbacher DM, Eswarakumar JV: FGFR2c-mediated ERK-MAPK activity regulates coronal suture development. Dev Biol. 2016 Jul 15; 2016 Mar 28. PMID: 27034231 Bagheri-Fam S, Ono M, Li L, Zhao L, Ryan J, Lai R, Katsura Y, Rossello FJ, Koopman P, Scherer G, Bartsch O, Eswarakumar JV, Harley VR: FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet. 2015 Dec 1; 2015 Sep 11. PMID: 26362256 Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP: Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013; 2013 Dec 12. PMID: 24371813 Gowthaman U, Eswarakumar VP: Molecular mimicry: good artists copy, great artists steal. Virulence. 2013 Aug 15; 2013 Jul 17. PMID: 23863600 Sims-Lucas S, Di Giovanni V, Schaefer C, Cusack B, Eswarakumar VP, Bates CM: Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme. J Am Soc Nephrol. 2012 Apr; 2012 Jan 26. PMID: 22282599 Sims-Lucas S, Cusack B, Eswarakumar VP, Zhang J, Wang F, Bates CM: Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development. 2011 Apr; 2011 Feb 24. PMID: 21350013 Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM: Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 2011 Jan. PMID: 21128305 Sims-Lucas S, Cullen-McEwen L, Eswarakumar VP, Hains D, Kish K, Becknell B, Zhang J, Bertram JF, Wang F, Bates CM: Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. Am J Physiol Renal Physiol. 2009 Nov; 2009 Sep 9. PMID: 19741018