Ehrlich, Barbara E - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of California at Los Angeles (1979) Post-Doctoral Fellow and then Instructor Departments of Physiology and Neuroscience, Albert Einstein College of Medicine, Incorporation of cardiac and Paramecium calcium channels in lipid bilayers. Post-Doctoral Fellow Marine Biological Laboratory, Woods Hole, MA. Lithium transport across squid axon membrane. Pre-Doctoral Student Brown University and Mount Desert Island Biological Laboratory, Providence, RI and Salsbury Cove, ME. Iodide transport in choroid plexus epithelium.

研究领域

Calcium; Polycystic Kidney Diseases; Pharmacology; Physiology; Hermeneutics

近期论文

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Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE. Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc Natl Acad Sci USA, 103(48), 18356-18361 (2006) Trisphosphate Receptor by O-GlcNAc Glycosylation. Rengifo, J., C.J. Gibson, E. Winkler, T. Collin, B.E. Ehrlich. Regulation of the Inositol (1,4,5)-Trisphosphate Receptor by O-GlcNAc Glycosylation. Journal of Neuroscience 27: 13813-13821 (2007). Chromogranin B regulates Ca2+ dependent and NF-kappaB mediated myocardial hypertrophic growth. Heidrich, F.M., M. Estrada, Y., Huang, F.J. Giordano and B.E. Ehrlich. Chromogranin B regulates Ca2+ dependent and NF-kappaB mediated myocardial hypertrophic growth. Circulation Research 102(10):1230-8 (2008). Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Petri, E.T., Ćelić, A., Kennedy, S.D., Ehrlich, B.E., Boggon T.J. & Hodsdon, M.E. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proceedings of the National Academy of Sciences, U.S.A., 107(20): 9176-81 (2010). Prevention of paclitaxel- induced peripheral neuropathy by lithium pretreatment. Mo, M., Erdelyi, I., Szigeti-Buck, K., Benbow, J.H. and Ehrlich, B.E. Prevention of paclitaxel- induced peripheral neuropathy by lithium pretreatment. FASEB J., 26(11):4696-709 (2012). Cyst formation following disruption of intracellular calcium signaling. Kuo, I.Y., DesRochers, T.M., Kimmerling, E.P., Nguyen. L., Ehrlich, B.E., & Kaplan, D.L. Cyst formation following disruption of intracellular calcium signaling. Proceedings of the National Academy of Sciences, 111(39):14283-8 (2014). Decreased polycystin 2 expression alters calcium-contraction coupling and changes beta-adrenergic signaling pathways. Kuo, I.Y., Kwaczala, A.T., Nguyen, L., Russell, K.S., Campbell, S.G. & Ehrlich, B.E. (2014). Decreased polycystin 2 expression alters calcium-contraction coupling and changes beta-adrenergic signaling pathways. Proceedings of the National Academy of Sciences, 111(46):16604-9 (2014) Moore LM, England A, Ehrlich BE, Rimm DL: Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival. Mol Cancer Res. 2017 Mar 8; 2017 Mar 8. PMID: 28275088 Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ: The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Mol Biol Cell. 2017 Jan 15; 2016 Nov 23. PMID: 27881662 Yi JS, Huang Y, Kwaczala AT, Kuo IY, Ehrlich BE, Campbell SG, Giordano FJ, Bennett AM: Low-dose dasatinib rescues cardiac function in Noonan syndrome. JCI Insight. 2016 Dec 8; 2016 Dec 8. PMID: 27942593 Wang B, Boeckel GR, Huynh L, Nguyen L, Cao W, De La Cruz EM, Kaftan EJ, Ehrlich BE: Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One. 2016; 2016 Aug 30. PMID: 27575489 Yang Y, Ehrlich BE: Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2. J Physiol. 2016 Aug 1; 2016 Apr 27. PMID: 26857659 Kuo IY, Duong SL, Nguyen L, Ehrlich BE: Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging. PLoS One. 2016; 2016 Apr 15. PMID: 27081851 Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE: Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail. Biochem J. 2016 Feb 1; 2015 Nov 16. PMID: 26574436 Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME: Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties. J Biol Chem. 2015 Apr 17; 2015 Feb 25. PMID: 25716316 DesRochers TM, Kuo IY, Kimmerling EP, Ehrlich BE, Kaplan DL: The effects of mycoplasma contamination upon the ability to form bioengineered 3D kidney cysts. PLoS One. 2015; 2015 Mar 20. PMID: 25793639 Kuo IY, Hu J, Ha Y, Ehrlich BE: Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels. J Biol Chem. 2015 Mar 6; 2015 Jan 21. PMID: 25609250 Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2; 2015 Feb 2. PMID: 25646377