Egan, Marie E - Yale University - Biological & Biomedical Sciences

个人简介

MD Mount Sinai School of Medicine (1986) Fellow The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Hospital Resident Johns Hopkins Hospital Intern The Johns Hopkins Hospital Board Certification AB of Pediatrics, Pediatrics (1990, recertified: 2017) Board Certification AB of Pediatrics, Pediatric Pulmonary Medicine (1992, recertified: 2017)

研究领域

Bacterial Infections; Cystic Fibrosis; Epithelial Cells; Genetic Code; Immunity, Innate; Inflammation; Lung; Macrophages; Microbiology; Pediatrics; Physiology; Pseudomonas aeruginosa; Clinical Trial; Macrophages, Alveolar; Cystic Fibrosis Transmembrane Conductance Regulator; Adaptive Immunity; Airway Management

近期论文

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Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis Bruscia E., PX. Zhang, A. Satoh, C. Caputo, R. Medzhitov, A. Shenoy, M.E. Egan D.S. Krause. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis, Journal of Immunology. 186: 6990-6998, 2011. (D.S.K. Macrophages directly contribute to the hyper pro-inflammatory response in Cftr -/- mice Bruscia E, Zhang P-X, Ferreira E, Caputo C, Emerson J, Krause D, Egan ME. Macrophages directly contribute to the hyper pro-inflammatory response in Cftr -/- mice. Am J Resp Cell & Mol Biol, 40:295-304, 2009. Curcumin, a major constituent of the spice tumeric, corrects cystic fibrosis defects Egan ME, Pearson M, Weiner S, Rubin D, Lukcas G, Du K, Rajendran V, Glockner-Pagel J, Canny S, Caplan MC. Curcumin, a major constituent of the spice tumeric, corrects cystic fibrosis defects. Science, 304:600-2, 2004. Assessment of CFTR activity in CFTR-null mice after bone marrow transplantation Bruscia EM, Grove JE, Chang EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of CFTR activity in CFTR-null mice after bone marrow transplantation, Proc Natl Acad Sci, 103:2965-70, 2006. Calcium pump inhibitors induce functional expression of DF508-CFTR in cystic fibrosis epithelial cells Egan ME, Ambrose CA, Cahill PA, Glockner-Pagel J, Balamuth N, Pappoe L, Cho T, Wagner CA, Geibel J, Caplan MC. Calcium pump inhibitors induce functional expression of DF508-CFTR in cystic fibrosis epithelial cells. Nature Med, 8:485-92, 2002. Rectal potential difference measurements and the functional expression of CFTR in the gastrointestinal epithelia of cystic fibrosis models Weiner SA, Caputo C, Bruscia E, Ferreira E, Price JE, Krause DS, Egan ME. Rectal potential difference measurements and the functional expression of CFTR in the gastrointestinal epithelia of cystic fibrosis models, Ped Res, 63(1):73-8, 2008. Egan ME: Effects of Lumacaftor/Ivacaftor in a Pediatric Cohort Homozygous for F508del-CFTR. Am J Respir Crit Care Med. 2017 Apr 1. PMID: 28362199 Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS: Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. J Am Soc Nephrol. 2017 Jan; 2016 Jun 16. PMID: 27313231 Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME: Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259 Egan ME: Genetics of Cystic Fibrosis: Clinical Implications. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857764 Hegan PS, Kravtsov DV, Caputo C, Egan ME, Ameen NA, Mooseker MS: Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI. Cytoskeleton (Hoboken). 2015 Sep; 2015 Sep 16. PMID: 26286357 Vanstone MB, Egan ME, Zhang JH, Carpenter TO: Association between serum 25-hydroxyvitamin D level and pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol. 2015 May; 2015 Feb 5. PMID: 25657016 McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME: Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nat Commun. 2015 Apr 27; 2015 Apr 27. PMID: 25914116 Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM: Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Adv Healthc Mater. 2015 Feb 18; 2014 Aug 25. PMID: 25156908 Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM: Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nat Commun. 2015 Feb 10; 2015 Feb 10. PMID: 25665524 Towle D, Callan DA, Farrel PA, Egan ME, Murray TS: Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. J Cyst Fibros. 2013 Sep; 2012 Dec 23. PMID: 23267773 Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM: Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. J Immunol. 2013 May 15; 2013 Apr 19. PMID: 23606537 Fields RJ, Cheng CJ, Quijano E, Weller C, Kristofik N, Duong N, Hoimes C, Egan ME, Saltzman WM: Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. J Control Release. 2012 Nov 28; 2012 Oct 5. PMID: 23041278 Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA: Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Traffic. 2012 Aug; 2012 May 8. PMID: 22510086