Craft, Joseph Edgar - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Joseph Craft is Paul B. Beeson Professor of Medicine and Chief of the Section of Rheumatology, and Professor of Immunobiology at the Yale University School of Medicine. He received his undergraduate degree in chemistry from the University of North Carolina at Chapel Hill, and is a graduate of the University of North Caroline School of Medicine. Dr. Craft then did postgraduate training in medicine and in rheumatology and immunology at Yale, and has been on the faculty at that institution since 1985. At Yale, he teaches graduate and medical students, and directs a research laboratory devoted to understanding T lymphocyte differentiation and function in normal and autoimmune responses. His research has been continually supported since 1985 by the National Institutes of Health, where he is a two-time NIH MERIT award recipient. Dr. Craft is Director of the Investigative Medicine Program at Yale, a unique program designed to provide Ph.D. training for physicians. He also is a Fellow of the American Association for the Advancement of Science and a member of the American Society for Clinical Investigation and the Kunkel Society, and Chair of the Executive Committee of the Lupus Clinical Investigators Network. He is former chair of the Immunological Sciences Study Section at NIH, and of the Scientific Advisory Board of the Alliance for Lupus Research, and a former Pew Scholar in the Biomedical Sciences. He is a co-founder of L2Diagnostics, a company in New Haven formed in partnership with Yale University and devoted to discovery of new diagnostics in vector-borne diseases and of targets for vaccine development, and is currently a member of its Board of Directors. MD University of North Carolina (1977) Fellow Yale University School of Medicine Resident Yale-New Haven Hospital Intern Yale-New Haven Hospital Board Certification AB of Internal Medicine, Internal Medicine (1980) Board Certification AB of Internal Medicine, Rheumatology (1988, recertified: 2008)

研究领域

Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Biology; Immunity; Lupus Erythematosus, Systemic; Investigative Techniques; Rheumatology; Cytokines

近期论文

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ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. Odegard J, Marks B, Eardley L, Poholek A, Kono D, Dong C, Favell R, Craft J. (2008). ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med. 205:2873-2886. PMCID: PMC2585848 Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Johnson RJ*, Poholek AC*, Yusuf I, DiToro D, Eto D, Barnett B, Dent AL, Craft J, Crotty S. (2009). Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 325:1006-1010 (*co-first authors). PMCID: PMC2766560 (Accompanied by a Perspectives article entitled “The Yin and Yang of follicular helper T cells” by Awasthi A & Kuchroo VJ, published in the same issue.) ICOS controls effector function, but not trafficking receptor expression, of kidney-infiltrating effector T cells in murine lupus. Odegard J, DiPlacido L, Greenwald L, Kashgarian M, Dong C, Flavell R, Craft J. (2009). ICOS controls effector function, but not trafficking receptor expression, of kidney-infiltrating effector T cells in murine lupus. J Immunol. 182:4076-4084. PMCID: PMC2746004 Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Marks BR, Nowyhed H, Choi J-Y, Poholek AC, Odegard J, Flavell RA, Craft J. (2009) Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation. Nat Immunol. 10:1125-1132. PMCID: PMC2751862. (Accompanied by News and Views article entitled “The importance of being earnestly selfish” by Cheroutre H, Mucida D & Lambolez F, published in the same issue.) Also see Corrigendum, Nature Immunol. 2010. 11:97. Competing for help: new insights into the function of follicular helper T cells. Poholek AC and Craft J. (2009) Competing for help: New insights into the function of follicular helper T cells. (News and Commentary; invited). Immunol Cell Biol. 87:438-439. 2009. In vivo regulation of Bcl6 and T follicular helper cell development. Poholek AC, Hansen K, Hernandez S, Eto D, Chandele A, Weinstein J, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. (2010) In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 185:313-326. PMCID: PMC2891136. Emerging from the shadows: follicular helper T cells in autoimmunity. DiPlacido L, Craft J. (2010) Emerging from the shadows: follicular helper T cells in autoimmunity (Editorial, invited). Arth Rheum. 62:6–8. PMCID: PMC2806501 Epstein-barr virus promotes interferon-alpha production by plasmacytoid dendritic cells Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft J. Arthritis Rheum. 62:1571-1575, 2010. PMCID: PMC2885535 Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. (2011) Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Cui W, Yiu L, Weinstein J, Craft J, Kaech SM. An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 35:792-805, 2011. PMCID: PMC3431922 Dissecting the immune cell mayhem that drives lupus pathogenesis. Craft JE. (2011) Dissecting the immune cell mayhem that drives lupus pathogenesis. The pathogenesis of SLE: An Update. Choi JY, Kim ST, Craft J. The pathogenesis of SLE: An Update. Curr Opin Immunol. 24:651-657, 2012. PMCID: PMC3508331 An IL-21/IL-10/STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Cui W, Yiu L, Weinstein J, Craft J, Kaech SM. Immunity. 35:792-805, 2011. PMCID: PMC3431922 T cells that promote B-Cell maturation in systemic autoimmunity.