Costa, Jose - Yale University - Biological & Biomedical Sciences

个人简介

Jose Costa, M.D., is Professor of Pathology and Medicine at Yale University School of Medicine. A graduate of Barcelona Medical School, Dr. Costa trained in Anatomical Pathology at Colorado University (G.B. Pierce) and Washington University (P. Lacy; L.V. Ackerman). He went on to do research as a Fogarty International Fellow (1973) in the laboratory of A.S. Rabson at NCI, were he stayed to eventually become the Anatomical Pathology Branch Chief at the Clinical Center, NIH Bethesda, MD. Elected to a Chair in Pathology at the University of Lausanne (1982), he directed between 1983 and 1993 the Institut Universitaire de Patologie, developing a program of advanced diagnostics and collaborating both with the ISREC and the Lausanne Branch of the Ludwig Institute. Dr. Costa joined the Yale Faculty in 1993 as Vice Chairman of Pathology and from 1995 until January 2007, he also served as Deputy Director of the Yale Comprehensive Cancer Center. Since 1998 he has been a member of the NCI's Early Detection Research Network. His laboratory investigates the micro-evolutionary dynamics involved in tumor formation and tumor progression using both experimental and theoretical modeling at the systems level. This work has identified novel and promising ways to detect early cancer and ways to follow the changes in tumors under therapy. In July, 2007, he assumed the direction of the Translational Diagnostics Program and the Musculoskeletal Program in the Department of Pathology at Yale. Dr. Costa remains an Emeritus Professor at the University of Lausanne, received the Trueta Medal for Sanitary Merit of the Catalan Government in 2002, and was elected Fellow of the American Association for the Advancement of the Sciences in 2003 for his work on tumor cell heterogeneity. He has served on numerous national and international committees and Scientific Advisory Boards, and has been Editor in Chief of Pathology Research and Practice and Laboratory Investigation. He presently serves as a member of the Consulting Team for the NCI’s Early Detection Research Network and also of the Scientific Advisory Board for the National Cancer Research Institute in Madrid (Spain). He has contributed over 160 original publications to the technical literature. MD University of Barcelona (1967) Senior Staff Fellow Laboratory of Pathology, NCI Visiting fellow Laboratory of Pathology, Fogarty International Foundation, NCI Resident Washington Univ School of Medicine Resident University of Colorado Medical Center Fellow National Institute of Health Fellow National Institute of Health Board Certification AB of Pathology, Anatomic Pathology (1974)

研究领域

Bone Neoplasms; Medical Oncology; Musculoskeletal Diseases; Orthopedics; Pathology; Molecular Diagnostic Techniques; Translational Medical Research

近期论文

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Spatial Dynamics in Cancer, in Complex Systems Science in Biomedicine Costa, J., Gonzalez-Garcia, I., and Sole, R. (2006). Spatial Dynamics in Cancer, in Complex Systems Science in Biomedicine (Deisboeck, T.S., and Kresh, J.Y.), Chapter 6.2, pp. 557-572. Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Lage, J.M., et al. (2003). Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Genome Res. 13:294-307. Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. Tallini G, Ghossein RA, Emanuel J, Gill J, Kinder B, Dimich AB, Costa J, Robbins R, Burrow GN, Rosai J. (1998) Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. Journal of Clinical Pathology, Vol 16(3): 1158-1166. The molecular biology of breast cancer: Accelerating clinical applications. Dillon DA, Howe CL, Bosari S, Costa J. (1998) The molecular biology of breast cancer: Accelerating clinical applications. Critical Reviews in Oncogenesis. 9(2): 125-140. Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer Bautista D, Obrador A, Moreno V, Cabeza E, Canet R, Benito E, Bosch X, Costa JC. (1997) Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer. Cancer Epidemiology, Biomarkers, and Prevention 6: 57-61. Ki-ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas. Pinto MM, Emanuel JR, Chaturvedi V, Costa JC. (1997) Ki-ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas. Acta Cytologica, 41 (2): 427-434. p53, apoptosis and colon cancer, Fazeli A, Steen RG, Dickinson SL, Bautista D, Dietrich WF, Bronson RT, Bresalier RS, Lander Es, Costa JC, Weinberg RA. (1997) p53, apoptosis and colon cancer, PNAS. A comparative study of the NCI and FNCLLL grading systems in a population of 410 adult patients with a soft tissue sarcoma Guillou L, Coindre J.M, Bonichon F, Biu NB, Terrier P, Collin F, Vilain M.O, Mandard A.M, ld Doussal V, Leroux A, Jacquemier J, Duplay H, Sastre X, Costa J.C. (1997) A comparative study of the NCI and FNCLLL grading systems in a population of 410 adult patients with a soft tissue sarcoma. J Clinical Oncology 15: 350-362. Benedict M, Costa J: Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma. Case Rep Pathol. 2016; 2016 Sep 28. PMID: 27774331 Samuel AM, Costa J, Lindskog DM: Genetic alterations in chondrosarcomas - keys to targeted therapies? Cell Oncol (Dordr). 2014 Apr; 2014 Jan 24. PMID: 24458248 Blumberg JM, Jedrych J, Costa J, Judson B: Cervical dedifferentiated liposarcoma with meningothelial-like whorling. Head Neck Pathol. 2012 Dec; 2012 Apr 21. PMID: 22528826 Huang X, Narayanaswamy R, Fenn K, Szpakowski S, Sasaki C, Costa J, Blancafort P, Lizardi PM: Sequence-specific biosensors report drug-induced changes in epigenetic silencing in living cells. DNA Cell Biol. 2012 Oct; 2012 Feb 7. PMID: 22313050 Costa J: Systems pathology: a critical review. Mol Oncol. 2012 Feb; 2011 Nov 27. PMID: 22178234 Krepkin K, Costa J: Defining the role of cooperation in early tumor progression. J Theor Biol. 2011 Sep 21; 2011 Jul 2. PMID: 21745479 Szpakowski S, Sun X, Lage JM, Dyer A, Rubinstein J, Kowalski D, Sasaki C, Costa J, Lizardi PM: Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements. Gene. 2009 Dec 15; 2009 Aug 21. PMID: 19699787 Costa J: Systems approach to the practice of pathology: a new role for the pathologist. Arch Pathol Lab Med. 2009 Apr. PMID: 19391643 Costa J: Is clinical systems pathology the future of pathology? Arch Pathol Lab Med. 2008 May. PMID: 18466023 Tarafa G, Tuck D, Ladner D, Topazian M, Brand R, Deters C, Moreno V, Capella G, Lynch H, Lizardi P, Costa J: Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis. Proc Natl Acad Sci U S A. 2008 Mar 18; 2008 Mar 12. PMID: 18337498