Colegio, Oscar Rene - Yale University - Biological & Biomedical Sciences

个人简介

Oscar R. Colegio, MD, PhD, is an Associate Professor of Dermatology, Pathology and Surgery at Yale School of Medicine where his clinical practice and research is focused on immunodeficiency-associated skin cancers and skin disorders associated with solid organ transplantation. His research has centered on defining the role of immune cells called macrophages in tumor progression. The focus of these studies has been to identify pathways of tumorigenesis critical to a variety of murine tumor types including lung carcinoma, melanoma, colon carcinoma and cutaneous squamous cell carcinoma. Parallel studies in identifying tumor-promoting pathways induced by infiltrating macrophages in human squamous cell carcinomas from immunosuppressed vs non-immunosuppressed patients is the current focus of the lab. Dr. Colegio was a Scholar of the Yale Center for Clinical Investigation and was supported by the Yale SPORE in Skin Cancer and the Dermatology Foundation. He is currently funded through the National Cancer Institute. Dr. Colegio is a member of several professional organizations related to his clinical and research interests. He is on the board of directors of the International Transplant Skin Cancer Collaborative, where he serves as the Director of the Committee for Research. Dr. Colegio is a graduate of The University of Texas, where he earned a BS in Pharmacy in 1995, and of Yale University where he earned a PhD in Cell Biology in 2003 and an MD, with election to Alpha Omega Alpha, in 2004. He completed an Internship in Internal Medicine and a Residency in Dermatology at Yale-New Haven Hospital during which time he was awarded the Hugh L. Dwyer Award for clinical excellence. MD Yale University School of Medicine (2004) PhD Yale University (2003) BS University of Texas at Austin (1995) Postdoctoral Fellow Yale Resident Yale Intern Yale Board Certification AB of Dermatology, Dermatology (2008)

研究领域

Allergy and Immunology; Carcinoma, Squamous Cell; Dermatology; Melanoma; Epithelial-Mesenchymal Transition

近期论文

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014 Sep 25;513(7519):559-63. Palmoplantar peeling secondary to sirolimus therapy. Liu LS, McNiff JM, Colegio OR. Palmoplantar peeling secondary to sirolimus therapy. Am J Transplant. 2014 Jan;14(1):221-5. Molecularly targeted therapies for nonmelanoma skin cancers. Liu LS, Colegio OR. Molecularly targeted therapies for nonmelanoma skin cancers. Int J Dermatol. 2013 Jun;52(6):654-65. Molecularly targeted therapies for melanoma. Liu LS, Colegio OR. Molecularly targeted therapies for melanoma. Int J Dermatol. 2013 May;52(5):523-30. Management of Non-Melanoma Skin Cancer in Immunocompromised Solid Organ Transplant Recipients. Bangash HK, Colegio OR. Management of Non-Melanoma Skin Cancer in Immunocompromised Solid Organ Transplant Recipients. Curr Treat Options Oncol. 2012 Sep;13(3):354-76. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. (2012) NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Skin cancer in transplant recipients, out of the woods. Scientific retreat of the ITSCC and SCOPE. Colegio OR, Billingsley EM. Skin cancer in transplant recipients, out of the woods. Scientific retreat of the ITSCC and SCOPE. Am J Transplant. 2011 Aug;11(8):1584-91. Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by cutaneous squamous cell carcinoma? Colegio OR, Kluger MS. Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by cutaneous squamous cell carcinoma? J Invest Dermatol. 2011 Jan;131(1):17-9. Prognosis of pretransplant melanoma. Colegio OR, Proby CM, Bordeaux JS, McGregor JM. Prognosis of pretransplant melanoma. Am J Tranplant. 2009 Apr;9(4):862. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminum adjuvants. Nature. Published online May 21, 2008. doi:10.1038/nature06939. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Colegio OR, Van Itallie CM, Rahner C, Anderson JM. Extracellular domains of claudins determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 2003 Jun 284(6):C1346-54. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Colegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol 2002 Jul; 283(1):C142-C147.